A Study of Blood Glucose, Serum Lipids and Antioxident Levels in Patients with Cataract

Document Type : Research Paper

Authors

Abstract

Introduction
Cataract is one the public health problem in the world and it is the most important cause of blindness in population. The aim of this study was to evaluatls levels of serum glucose, lipids and Antioxident in patients with cataract.
Materials and Methods
In this case-control study, we have compared serum glucose, lipids and Antioxident levels of 90 cataract patients (Case group) with 90 healthy volunteers (control group) at Birjand Valiassr hospital. Then the data entered in to SPSS software, analyzed with X2 and regression logestic at a=0.05.
Results
In two groups 50% of subjects were males. Mean age in case group was 60.2±8 years and in control group was 58.3±8.7 years (p=0.13). Mean levels of Chol, TG and LDL in case group were significantly higher than control group. The levels of hypercholesterolemia, hypertriglyceridemia, high glucose and low HDL in case group were higher than control group. Also, MDA and lipid peroxidation were higher in case group.
Conclusion
High glucose,dyslipidemia and low level of antioxidant may effect on cataract.Routinevaluation of serum lipids in CAD patients who suffer from diabetes mellitus is necessary, due to high prevalence of dyslipidemia in this high risk group. These findings indicate a need for health promotion activities for the control of mentioned factors.

Keywords


1- Tasman W, Jaeeger EA. Duane's clinical ophthalmology.Philadelphia-New York: Lpincott-Raven; 1995.vol.p.1-12.
2- Yanoff M, Duker JS. Oftalmology. 2nded.2005.p.270.
3- Rabiu MM. Cataract blindness and barriers to uptake of cataract surgery in a rural community of northen Nigeria. Br
J Ophthalmol 2001; 85:776-780.
4- Andreoli TE, Carpenter CCJ, Griggs RC, Benjamin I, et al. Essentials of medicine. 5th ed Philadelphia: Saunders;
2001.p.42.
5- Leske MC, Chylack LT, Ir, WU SY. The lens opacities cace-control study .Risk factors for Cataract: Arch
ophthalmol 1991; 1099:244-251.
6- Ipchi SH, Hasanzadeh D, Mahboob SA, Safaeian AR, Rashidi MR, Zare JA. Plasma determination of copper, zinc
and iron in cataract and non – cataract patients. J Pharmacol sci Tabriz Med Univ 2000; 3:1-8.
7-Leske MC, USY, Hennis A,Connell AM, Hyman L,Schachat A. Diabetes,hypertension,and central obesity as cataract
risk factors in black population the Barbados Eye study. Ophthalmology 1999:106:35-41.
8- Mahboob SA, Rashidi MR, Hasanzadeh D, Zare JA , Ipchi SH. Sesum plasma vit A ratio and senile cataract. J
Urmieh Univ med sci 2002; 1:8-15.
9- Klein BE, Klein R, Lec KE. Cardiovascular disease selected cardiovascular disease risk factors and the 5 year
incidence of age related cataract and progress of lens opacities: the Beaver Dam Eye study. Am J ophthalmol 2001;
126:782-790.
10- Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as measure of a antioxidant power: the FRAP
assay. Anal Biochem 1996; 239:70-76.
11- Corongiu FP, Milia A. An improved and simple method to determining diene conjugation in autoxidised poly
unteraction s .Chem Biol Interact 1983; 44:289-297.
12- Miratashi AM, Ahmadieh MH, Taghvaii M, Bakhtiari A. Survey of cholesterol and Triglyceride in catarac patiens.
J Shahid Sadooghi Univ Med Sci 1998; 1:16-19.
13- Meywr D, parklin O, Maritz F, liebenbery PH. Abnormal serum lipoprotein lerels as a risk factor for the
development of human lenticular opacities. Cardiovascular JS Afr 2003; 14:60.
14- Hiller R, Sperduto RD, Reed GF, D Agostino RB, Wilson PW. Serum lipids and age related lens opacities: a
longitudinal investigation the framingham studies. Ophthalmology 2003:110:578-583.
15- Roue NG, Mitchell PG, Cumming RG, WansJJ. Diabetes fasting blood glucose and age-related Cataract: the Blue
Mountains Eye study. Ophthalmolmic pidemiol 20007:103-114.
16- Ravanshad S, Salooti R, Maram ES. Antioxidant status In persons with and without senile cataract. Pak J Med Sci
2004; 2:121-123.
17- Zare JA , Mahboob SA , Rashidi MR, Arefhoseini SR, Rahimi AR, Safaeian AR, et al. Comparative study of
plasma vit C ratio and nutrition in senile cataract and healthy participants. J Ghazvin Univ Med sci 2002; 24:9-14.
18- Mahboob SA, Rashidi MR, Hasanzadeh D, Zare JA , Ipchi SH. Sesum plasma vit A ratio and senile cataract. J
Urmieh Univ med sci 2002; 1:8-15.
19- Rahbani MB, Noori M, Rashidi MR, Rashidi MR, Sajadi SA. Plasma level of vit E and malone dealdehyide. J
Tabriz Univ Med sci 2003; 58:18-21.
20- Taylor A, Chiu C.J. Nutritional antioxidant and age-related cataract and maculopathy. Experimental Aye Research
2007; 84:229-245.
21-Vinson JA. Oxidative stress In cataract. Patophysiology 2006; 13:151-162.
22- Thiagarajan G, Chandani S, Sundari CS, Rao SH, Kulkarni AV. Antioxidant properties of green and black tea and
their potential ability to retard the progression of eye lens cataract. Experimental Aye Research 2001; 73:393-401.