Evaluating the Correlation between HbA1c and Growth Parameters, Lipid Profile in Children and Adolescents with Type 1 Diabetes

Document Type : Research Paper

Authors

1 Associate professor ofPediatrics diseases, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

2 Assistant Professor of Hematopathology, Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction
Type1 diabetes is the most common endocrine disorder in children. The disease is associated with a variety of complications including growth abnormalities. The aim of this study was to evaluate the role of diabetes and blood sugar control on physical growth (height and weight), growth parameters and lipid profile.
Materials and Methods
This descriptive cross- sectional study took place from July 2006 to July 2007. A total of 154 children and adolescents with diabetes type 1, evaluated for their growth parameters, lipid profile٫ and its correlation with duration of diabetes and mean HbA1C.
Results
The mean age of diabetes diagnosis recorded 6.2±3.1 year. The mean height growth velocity was 4.8±1.48 cm and the mean weight growth velocity 3±1.5 kg in one year. In the first group with HbA1c< 8 (mean±1sd) height and weight growth velocities were 4.8±1.3 cm and 3.03±1.6 kg in a year respectively. In the second group with HbA1c > 8 (mean±1SD), yearly height and weight growth velocities measured 3.2±1.22 cm and 3.03±1.2 kg in turn. Moreover, in the first group TC, LDL, HDL and TG were 163.1±34 mg/dl, 109.3±22 mg/dl, 49.5±1 mg/dl, 116.3±55 mg/dl and in the second group 172.6±46 mg/dl, 122.4±80 mg/dl, 48.5±1 mg/dl, 153.3±1.5 mg/dl in the order mentioned. In the group with disease duration less than 5 years, height and weight growth velocities were 5.7±1.4 cm and 3.3±1.6 kg and in group with disease duration more than 5 years, height and weight velocities reported 3.74±1.2 cm and 3.3±1.2 kg annually respectively.
Conclusion
According to this study, there was no correlation between the mean of height, weight growth velocities and metabolic control in both groups. However, the hight growth disorder and increase in the level of TG were correlated with the duration of disease. Also, lipid profile (dislipidemia) was associated with the lack of metabolic control.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 51, Issue 4 - Serial Number 4
November and December 2008
Pages 197-202

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