Leukocyte Adhesion Deficiency

Document Type : Case report

Authors

1 Assistant professor of Immunology and Allergy Mashhad University of Medical Sciences, Mashhad, Iran

2 Associate professor of Hematology/Oncology, Mashhad University of Medical Sciences

Abstract

Introduction
Leukocyte adhesion deficiency (LAD) is a rare functional leukocyte disorder, which is divided into two separate types: LAD-1 and LAD-2. LAD-1 results from lack of b2 integrin molecules (CD11 & CD18) on the leukocyte cell surface. These molecules are essential for leukocyte adhesion to endothelial cells and chemotaxis.
The present case report is about a 42-month-old girl with recurrent otitis, pneumonia and gingivitis. On physical examination, patient was pale and malnourished. Multiple desquamated erythematous plagues were found on her body and extremities. Blood investigations revealed persistent leukocytosis with normal serum Immunoglobulin profile and complement. The diagnosis of LAD1 was made based on Flow cytometry finding; showing decreased in CD11 and CD18 markers of PMN a.
Conclusion
When a patient has persistent leukocytosis and recurrent infections, investigation for the primary immune deficiency, specially leukocyte adhesion deficiency must be considered.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 51, Issue 4 - Serial Number 4
November and December 2008
Pages 243-246

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