Role of Fibrin/Fibrinogen Degradation Products in Prognosis of Patientswith Head Trauma

Document Type : Research Paper




ntroduction: Accident is the third common cause of mortality in population .Traumatic head injury is the most common cause of mortality among these events. In different studies, coagulation disorder is one of the most important factors for determination of severity of injury. The present study was designed to evaluate post traumatic fibrinolysis in adults after head injury.
Material and Methods: In this descriptive cross sectional study, ninety six patients (22 patients with mild head injury and 74 patients with severe or moderate head injury), who admitted in Mashhad Shahid Kamyab Hospital for six months, were chosen randomly. All of them had only head injury and admitted in hospital in less than 6 hours after trauma. The clinical & paraclinical findings including FDP were evaluated. Data was gathered in a questionnaire and analyzed by descriptive statistics and frequency distributes tables.
Results:Most cases of delayed hematoma happened within 14 hours of trauma. FDP value was correlated with severity of head injury and there was a meaningful correlation between FDP value and GCS. Higher FDP was seen with lower BMR, and vise versa. The most common cases with delayed hematoma were intracerebral hematoma.
Conclusion: FDP may be a valuable predictive factor in traumatic head injury and changes in coagulation cascade may improve the outcome of patients with traumatic head injury.


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