Crimean Congo hemorrhagic fever in the Razavi Khorasan province of Iran

Document Type : Research Paper


1 Associate Professor of Infection Disease, Mashhad Universitiy of Medical Sciences, Mashhad, Iran

2 Specialist in Infection Disease, Mashhad, Iran


CCHF is a health problem in Iran and khorasan. The main purpose of this study was to determine the most important clinical characteristics, complications and risk factors   of disease acquisition.
Materials and Methods:
 In this case-series study, 29 patients with confirmed diagnosis of CCHF, reported to the health center of Khorasan, province of Iran were studied. Epidemiologic, demographic and clinical picture were examined.
In this study, 12 (41.1%) cases were male and 17 (58.6%) were female, with a mean age of 31 (±15) years. Most of patients were admitted in summer.Clinical features included: high fever (93.1%), nausea & vomiting (75.9%), headache (72.4%), myalgia (72.4%), hemorrhagia (72.4%). Laboratory abnormalities were: anemia, leukopenia, thrombocytopenia, increased AST/ALT levels, prolonged bleeding time, prothrombin time (PT), and activated partial thromboplastin time (PTT). Contact with livestock, working in slaughterhouse, consumption of Crude liver, and living in the village were risk factors for acquisition of infection. The incubation period was 3 (±1). The most common differential diagnosis was immune (idiopathic) thrombocytopenia (17.2%).
Contact with livestock, working in slaughterhouse, consumption of raw liver, and living in villages, the short incubation period [3 (±1)] ,further increase in lactate dehydrgenase & aspartate transferase levels, leukocytosis and further reduction in platelet count, are more likely to prove the diagnosis of disease . Risk factors of death included: severe leukocytosis, critical bleeding (respiratory & gastrointestinal).