Introduction
Results of studies revealed that there is relationship between cardio-vascular diseases and sedentary lifestyle. According to these results, the new markers of cardio-vascular diseases are more sensitive in predicting these diseases. The purpose of this study was to compare the inflammatory marker of HS-CRP and TG, LDL-c and HDL-c in active and non-at HS-CRP, TG, LDL-c, HDL-c, activemiddle-aged women ive and middle-aged women.
 Materials and Methods
The present research was causal-comparative. A total of 30 women with the mean age of: 41/34±3/51 year, heigh: 158/89±5/136 cm, weight: 76/69±4/749 kg, BMI: 27/61±1/96 kg/m² participated in this research. They were randomly divided in to two groups (active group, n=15, non-active group, n=14). Active group of women had regular physical activity for one year and non active group didn`t have any physical activity in the past year. In this study, the Kulumogrof-Smirnof test to assume normality of data and also independent groups T-test were used to compare means.                                                                                    Results
Findings showed that there were significant differences in the level of Hs-CRP (P=0/001) and HDL-c (P=0/001) in active and non-active groups. But there was no significant difference between the two groups in the level of LDL-c (P=0/982) and TG (P=0/777).
Conclusion
According to the results regular physical activities can probably be effective in preventing cardio-vascular diseases in overweight middle-aged women.