Correlation of Urinary Albumin Creatinine Ratio with Gasometric Parameters in Patients with Chronic Obstructive Pulmonary Disease (COPD)

Document Type : Research Paper


1 Assistant Professor of Nephrology, Kidney transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad ,Iran

2 Associate Professor of pulmonary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 General Physician, Mashhad, Iran

4 Assistant Professor of pulmonary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5 Associate Professor of Nephrology, Chronic Renal Failure Research Center, Jundishapour University of Medical Sciences, Ahvaz, Iran


To assess urinary albumin rate (urinary albumin to creatinine ratio: UACR) in patients with chronic obstructive pulmonary disease (COPD), and to determine its correlation with gasometrical parameters
Materials and Methods
In this description cross-sectional study, twenty-one cases (Male: 13, Female: 8) with COPD who had been hospitalized because of an acute exacerbation were included. We measured UACR, arterial blood gas analysis (Pa O₂, pH and pCO2). UACR between 30 to 300 mg/gr was accepted as microalbuminuria. Pearson’s correlation coefficient method was used to assess correlation between UACR with gasometrical parameters.
The mean age of patients was 64.84 ± 10.20.  Microalbuminuria was detected in 9 (56%) subjects. There was a negative correlation between PaO₂ and UACR (r = -0.40, P < 0.001). There was no relation between the UACR values and arterial pH and pCO2.
Based on the results in COPD patients, Microalbuminuria was common and may have relation with hypoxemia in them. Further studies are necessary to determine whether these changes are progressive or have any prognostic relevance in patients with COPD.