Molecular Signaling Pathways involved in Temporal Lobe Epilepsy

Document Type : Review article

Authors

1 Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.

2 Department of Clinical Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran.

4 Department of Neuroscience, Mashhad University of Medical Science, Mashhad, Iran

Abstract

Epilepsy is a chronic neurological disorder that defined as a disorder of recurrent seizures and characterized by an imbalance of excitation and inhibition in the brain. Despite many efforts in recent years, one-third of the epileptic patients are refractory to medical treatment.  It has been reported that genetic factors, synaptic ion channels, excitatory and inhibitory neurotransmitters and activation of various receptors such as ionotropic and metabotropic glutamate receptors in the central nervous system can promote epileptogenesis. Further research to investigate the molecular mechanisms and ions involved in the development of epilepsy is needed. In this review, we present an overview of current status into the molecular signaling pathways involved in epileptogenesis. Furthermore, we will focus on temporal lobe epilepsy (TLE) molecular mechanisms. Understanding of molecular mechanisms could provide new fascinating insights into drug target identification in the prevention of epileptogenesis.
 

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 61, Issue 4
January and February 2019
Pages 1143-1153

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