Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

Correlation of STAT4 gene Polymorphism (rs3024839) with risk of myocardial infarction (MI)

Document Type : Research Paper

Authors
Zahra Khosravi Nezhad 1
Siros Naeimi 2
Mohammad Mahdi Moghanibashi 1
Khalil Khashei Varnamkhasti 1
1 Department of Genetics, Colleague of Science, Kazerun branch, Islamic Azad University, Kazerun, Iran
2 Department of Genetics, Colleague of Science, Kazerun branch, Islamic Azad University, Kazerun, Iran.
10.22038/mjms.2022.62362.3654
Abstract
Background: The studies have demonstrated that Signal transduction and activation of transcription (STATs) play a major role in atherosclerotic plaque disruption and lead to myocardial infarction (MI). The present study was done to investigate the association between the STAT4 gene polymorphism in site of rs3024839 with the risk of developing MI in an Iranian population.
Material and Methods: This is a case-control study. The possible association between STAT4 polymorphism (SLC6A4) with the development of MI was investigate in a group of 200 patients with a history of MI and 200 healthy controls. The two groups were matched in terms of TCe and sex. After DNA extraction and replication, Genotypes and alleles frequency were determined in two groups using polymerase chain reaction (PCR-ARMS). The results were analyzed by SPSS software using Chi-square and logistic regression tests.
Finding: The result showed a significant difference in the rates of TC STAT4 genotype between MI and control groups (p=0.03). There was not any significant relationship between STAT4 gene polymorphisms and risk factor of MI such as sex, hypertension, dyslipidemia, diabetes, type of MI (STEMI or NSTEMI) (P>0.05).
Conclusion: The results of presented study reveal that the rs3024839 T/C polymorphism of the STAT4 gene probably plays a specific role in the risk of developing MI in Iranian population. But, further well-designed studies with large sample sizes are required to confirm our results.
Keywords
STAT4 gene
polymorphism
Myocardial infarction
rs3024839
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Medical Journal of Mashhad university of Medical Sciences
Volume 65, Issue 1
May and June 2022
Pages 12-20