No change in HDL in the presence of increased paraoxonase-1 in response to TRX training in obese middle-aged obese women

Document Type : Research Paper

Authors

1 Master of Sciences of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran

2 Assistant Professor of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran

Abstract

Introduction: Scientific evidence suggests a reduction in the anti-atherogenic and antioxidant effects of paraoxonase-1 (PON1) in the presence of obesity. The aim of this study was to determine the effect of 8 weeks TRX on PON1 and HDL in inactive middle-aged obese women.
Methods: For this purpose, 28 sedentary middle-aged obese women aged 30-40 years of old (30 ≤ BMI ≤ 36) were randomly divided into of TRX (8 weeks, 3days/weekly, n= 14) and control (no training, n = 14) groups. Fasting levels of PON1 and HDL and anthropometric indices (Weight, abdominal circumference, body mass index, visceral fat, body fat percentage) were measured before and 48 hours after lasted exercise session in both groups. Independent and paired t-test was used to compare baseline levels and changes in variables between the two groups before and after the training program.
Results: TRX training led to a significant increase in PON1 (p= 0.016) a significant decrease in anthropometric indices (p < 0.05) and but HDL did not change significantly (p = 0.087). None of these variables were changed in the control group (p > 0.05).
Conclusion: Despite no change in HDL, TRX training by increasing PON1 is associated with antioxidant and anti-atherogenic effects in obese middle-aged women.

Keywords

References

  1. Mathieu P, Poirier P, Pibarot P, Lemieux I, Després JP. Visceral obesity: the link among inflammation,
    hypertension, and cardiovascular disease. Hypertension 2009; 53(4):577-84.
    2. Ayatollahi S, Ghoreshizadeh Z. Prevalence of obesity and overweight among adults in Iran. Obesity Reviews
    2010; 11(5):335-37.
    3. Piché ME, Tchernof A, Després JP. Obesity Phenotypes, Diabetes, and Cardiovascular Diseases. Circ Res.
    2020 May 22; 126(11):1477-1500.
    4. El-Lebedy D, Kafoury M, Abd-El Haleem D, Ibrahim A, Awadallah E, Ashmawy I. Paraoxonase-1 gene
    Q192R and L55M polymorphisms and risk of cardiovascular disease in Egyptian patients with type 2 diabetes
    mellitus. J Diabetes Metab Disord 2014; 13(1): 124.
    5. Farid AS, Horii Y. Modulation of paraoxonases during infectious diseases and its potential impact on
    atherosclerosis. Lipids Health Dis 2013; 23(11):92.
    6. Afzalpour MS, Gharahkhanloo R, Gaeeini AA, Maleknia N. The effect of moderate and vigorous aerobic
    training on serum paraoxonase 1 (PON1) activity and serum lipid profile in healthy non-athletic men.
    Olympic, 1398; 2(50): 61-72.
    7. Koncsos P, Seres I, Harangi M, Páll D, Józsa L, Bajnok L, et al. Favorable effect of short-term lifestyle
    intervention on human paraoxonase-1 activity and adipokine levels in childhood obesity. J Am Coll Nutr
    2011; 30(5):333-9.
    8. Sang H, Yao S, Zhang L, Li X, Yang N, Zhao J, et al. Walk-run training improves the anti-inflammation
    properties of high-density lipoprotein in patients with metabolic syndrome. J Clin Endocrinol Metab 2015;
    100(3):870-9.
    9. Ahmadi M, Abbasi Daloeii A, Behboudi L. Comparison between the effects of eight weeks of aerobic and
    resistance training on paraoxonase-1, arylesterase activity and lipid profile in obese girls. Scientific Journal
    of Kurdistan University of Medical Sciences. 2016; 21(4): 83-93.
    10. Ghorbanian B, Shokrollahi F. The effects of rope training on Paraoxonase-1 enzyme, insulin resistance and
    lipid profiles in inactive girls. Tehran Univ Med J. 2017; 75 (4): 307-315
    11. Tas M, Zorba E, Yaman M. Comparison of the effects of different training methods on arylesterase
    activity and paraxonase activity levels in hot environment. TOJRAS: The Online Journal of Recreation
    and Sport, 2012; 1: 1-8.
    12. Housini S L, Eizadi M. The effect of 8 weeks TRX training on glutathione peroxidase (GPx) and hydrogen
    peroxide (H2O2) in sedentary middle-aged obese men. RJMS. 2020; 27 (5): 210-219.
    13. Kosmata, A. Functional Exercise Training with the TRX Suspension Trainer in a Dysfunctional, Elderly
    Population. Department of Health and Exercise Science. 2014.A
    14. Baghaiee B, Siahkuhian M, Hakimi M, Bolboli L, Ahmadi Dehrashid K. The Effect Paraoxonase-1,
    Hydrogen Peroxide and Adiponectin Changes on Systolic and Diastolic Blood Pressure of Men’s with High
    Blood Pressure Fallowing to 12 Week Moderate Aerobic exercise. J Shahrekord Univ Med Sci. 2016; 18
    (1):81-92.
    15. Aicher BO, Haser EK, Freeman LA, Carnie AV, Stonik JA, Wang X, et al. Diet-induced weight loss in
    overweight or obese women and changes in high-density lipoprotein levels and function. Obesity 2012;
    20(10): 2057-62.
    16. Nalcakan GS, Rana V, Faruk T, Mesut NM, Zeki OS, Oguz K. Effects of aerobic training on serum
    paraoxonase activity and its relationship with PON1-192 phenotypes in women. Journal of Sport and Health
    Science. 2016 Dec;5(4):462-468
    17. Roberts CK, Ng C, Hama S, Eliseo AJ, Barnard RJ. Effect of a short-term diet and exercise intervention on
    inflammatory/anti-inflammatory properties of HDL in overweight/obese men with cardiovascular risk
    factors. J Appl Physiol 2006; 101(6): 1727-32.
    18. Atli M. Serum paraoxonase activity and lipid hydroperoxide levels in adult football players after three days
    football tournament. Afr Health Sci. 2013; 13(3): 565-70.
    19. Ghasemi E, Afzalpour ME, Saghebjoo M, Zarban A. The effect of short-term green tea supplementation on
    total antioxidant capacity and lipid peroxidation in young women after an intense resistance training session.
    Journal of Esfahan Medical School.1391; 30(202): 1367-76.
    20. Otocka-Kmiecik A, Orłowska-Majdak M. The role of genetic (PON1 polymorphism) and environmental
    factors, especially physical activity, in antioxidant function of paraoxonase. Postepy Hig Med Dosw (Online).
    2009 Dec; 63:668-77.
    21. Ansell BJ, Watson KE, Fogelman AM, Navab M, Fonarow GC. High-density lipoprotein function: recent
    advances. J Am Coll Cardiol 2005; 46(10): 1792-1798.
  2. 22. Zahabi Gh, Barari AR, Ahmadi M. Effect of Concurrent Training on Paraoxonase Activity Levels and Some
    of the Lipid Plasma Markers in the Blood of Women without Exercise Activity. Journal of Paramedical
    Science and Rehabilitation. 2015; 4(1): 15-23.
    23. Casella-Filho A, Chagas ACP, Maranhao RC , Trombetta IC, Cesena FH, Silva VM, T et al. Effect of
    exercise training on plasma levels and functional properties of high-density lipoprotein cholesterol in the
    metabolic syndrome. Am J Cardiol 2011 ;107(8): 1167-1172.
Medical Journal of Mashhad university of Medical Sciences
Volume 65, Issue 3
May and June 2022
Pages 1071-1079

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