Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

Relationship between surgical antibiotic prophylaxis and nosocomial infection in intensive care units

Document Type : Research Paper

Authors
Ehsan Motaghi 1
Razieh Gerami 2
Masumeh Ghasemi 3
Shahin Jafarpour 4
Mohammad Javad Hosseini 5
1 Department of Physiology and Pharmacology, School of Medicine, Kurdistan University of Medical Sciences.
2 Shiraz University, Collage of veterinary, Basic Science Section
3 Immunology Department,, School of Medicine, Shahrekord University of Medical Science
4 Department of Infectious disease, School of Medicine, Tehran University, Tehran, Iran
5 Department of infectious disease, School of medicine, Tehran university, Iran
10.22038/mjms.2022.63964.3754
Abstract
Background and aim: Nosocomial infections (NIs) during ICU admission may cause morbidity, mortality and hospital readmissions. The aim of this study was to determine risk factors of nosocomial infections in ICUs with an emphasis on preoperative antibiotic prophylaxis.
Method: A retrospective study of NIs was conducted in ICUs of a public hospital in Iran between October 2019 and May 2020. The overall rate of NI, distribution of the infection sites and responsible pathogen and the length of ICU stay as well as the risk factors of NIs were investigated.
Results: The rate of NIs in patients receiving one preoperative antibiotic was much lower than that in patients receiving more than one antibiotics (p<0.001). Long-term pre-operative antibiotic prophylaxis or use of broad spectrum surgical prophylaxis increased the risk of NIs in ICUs.
Conclusions: The results indicated that using of more than one antibiotic as preoperative prophylaxis is associated with higher risk of NIs. Moreover, administration of broad spectrum antibiotics as preoperative prophylaxis increase the risk of NIs in critically ill patients.
Keywords
Acinetobacter
Nosocomial infections
infection inhibition
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Medical Journal of Mashhad university of Medical Sciences
Volume 65, Issue 3
May and June 2022
Pages 1105-1112