The effect of five weeks of intense intermittent training on the expression of RXFP1 and CTGF genes in heart tissue and liver enzyme SGPT in male Wistar rats with fatty liver.

Document Type : Research Paper

Authors

1 Phd student of exercise physiology, Department of Physical Education, Borujerd branch, Islamic Azad University, Borujerd, Iran

2 1- Assistant Professor of Exercise Physiology, Department of Physical Education, Borujard Branch, Islamic Azad University, Borujard, Iran

3 Associate Professor of Sports Physiology, Sports Physiology Research Center, Lifestyle Research School, Baqiyatullah University of Medical Sciences, Tehran, Iran

Abstract

Background and purpose: In recent years, studies have been conducted on the relationship between fatty liver and atherosclerosis, and the results of these studies indicate the relationship between non-alcoholic fatty liver and atherosclerosis of coronary arteries. Fatty liver is associated with increased risk of cardiovascular diseases. An increase in the thickness of the intima-media layer of the carotid artery and stenosis of the common carotid artery secondary to carotid plaques are indicators of atherosclerosis. The aim of this study was the effect of high intensity interval training (HIIT) on the expression of cardiac 1 RXFP and CTGF genes in male rats with fatty liver steatosis model.
Materials and methods: 48 male Wistar rats weighing 230-300 g in 6 basic healthy groups (BH), modeled basic group (steatosis) (BS), healthy HIIT group (HIIT), modeled HIIT group (steatosis) SHIIT), healthy control group (CH), modeled control group (steatosis) (CS) were randomly divided. Rats in the fatty liver group received oral tetracycline daily for two weeks. The rats of the training groups were also trained for 5 weeks/5 days. Two groups, BS and BH, were sacrificed at the end of the second week, and the training groups and the CS group were sacrificed at the end of the 5th week, and heart tissue samples were taken to examine the expression of SGPT genes. , RXFP1 and CTGF were taken.
Findings: The amount of SGPT in BS and CS groups was significantly higher than the other 4 groups.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 65, Issue 2
May and June 2022
Pages 601-616

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