Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

The Relationship Between Breast Cancer And Vitamin D Serum Level In Infected And Non-Infected Patients Referred To Surgery Clinics

Document Type : Research Paper

Authors
Shahrzad Mehrmovahed 1
Shohreh Mehrmovahed 2
1 Department of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
2 Department of Neurology, Gilan University of Medical Sciences, Rasht, Iran.
10.22038/mjms.2021.22556
Abstract
Introduction: Breast cancer is the most common cancer among women, which causes heavy costs to the patient and the society. The active role of vitamin D in preventing many diseases has been proven. This study was conducted with the aim of determining the relationship between breast cancer and vitamin D serum level in affected and non-affected patients referred to surgery clinics.
Method: This study was designed as a case-control and retrospective. Breast cancer patients referred to Rasht and Tonekabon clinics were diagnosed with breast cancer by specialist surgeons and by referring to the pathology results, and then the same number of people were healthy in terms of vitamin D levels and at the end with were compared. Vitamin D was measured by RIA kit. Also, a significance level of 0.05 was considered.
Results: Using Fisher's Exact test, it was determined that there is a statistically significant relationship between women's age groups, body mass index and living conditions, and blood vitamin D3 levels in the group of women with breast cancer (P=0.005. Also, the incidence of breast cancer in the vitamin D3 deficiency group (less than 29 mmol/l) was 62%, while this rate was 38% in the normal vitamin D3 group (more than 30 mmol/l).
Conclusion: Vitamin D deficiency has a direct role in the incidence of breast cancer in women, so that the findings have provided convincing experimental evidence to prove the inverse relationship between vitamin D levels and the risk of developing breast cancer. Also, other factors such as living conditions and body mass index also play a role in increasing its incidence.
Keywords
Cancer disease
breast cancer
vitamin D serum level
women
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Medical Journal of Mashhad university of Medical Sciences
Volume 64, Issue 3
September and October 2021
Pages 3469-3479