Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

COVID-19 prognosis with the use of renin-angiotensin-aldosterone system inhibitors

Document Type : Research Paper

Authors
Shima Shahrabadi 1
Saeid Eslami 2
Fereshteh Sheybani 3
Masoumeh Akbari 4
Zhila Taherzadeh 5
1 Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Medical Informatics,, School of Medicin, Mashhad University of Medical Sciences, Mashhad, Iran
3 Departments of Infectious Diseases and Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Persian cohort research center, Mashhad University of Medical Sciences, Mashhad, Iran
5 Faculty of Pharmacology and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/mjms.2023.73975.4371
Abstract
Objective: This study was carried out with the aim of expressing the prognosis of COVID-19 with a history of taking drugs affecting the renin-angiotensin system in affected patients.
Method: In this cross-sectional observational-analytical study, the information of patients who were referred to Imam Reza (AS) hospital with suspected symptoms of COVID-19 from March 2018 to May 1400, was extracted from the registry system of Imam Reza (AS) Mashhad Hospital. Demographic information, underlying diseases and simultaneous use of other drugs, drugs used in the treatment of COVID-19, body temperature, blood oxygen level, progression of COVID-19, on the day of admission and the day of discharge in 139 patients with COVID-19 with history of use drugs affecting the renin-angiotensin system in the management of blood pressure (group A) were compared with 67 patients with COVID-19 who had no history of taking drugs affecting the renin-angiotensin system in the management of blood pressure. The duration of hospitalization and the final outcome (improvement/death) were also recorded for the patients.
Results: There was no statistically significant relationship between the history of taking drugs affecting the renin-angiotensin system with the mortality rate (p=0.72) and clinical parameters such as the severity of the COVID-19 disease (p=0.64), fever (p=0.72) and the level of oxygen in the blood (p=0.40).
Conclusion: The history of taking drugs affecting the renin-angiotensin system does not play a major role in the exacerbation of the disease of COVID-19 or the increase in mortality in patients with hypertension.
Keywords
Renin-angiotensin-aldosterone system
Covid-19
Coronavirus disease
Angiotensin-converting enzyme inhibitors
Angiotensin receptor blocker
Subjects
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Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 2
March and April 2024
Pages 384-398