Comparative study of the infusion of ketorolac and Pethidine in reducing postoperative pain in patients undergoing orthopedic surgery of lower limbs under spinal anesthesia

Document Type : Research Paper

Authors

1 Department of Orthopedics, Jahrom University of Medical Sciences, Jahrom, Iran.

2 Department of Anesthesiology, Jahrom University of medical sciences, Jahrom, Iran.

3 Student research committee, Jahrom University of medical sciences, Jahrom, Iran

Abstract

Introduction: Pain after surgery is an unpleasant experience that occurs following various stimuli and people react to it. This process causes physiological disorders in all systems of the body.
Method: In this three-way, randomized clinical trial, 59 patients with anesthesia classes 1 and 2 underwent lower limb orthopedic surgery with spinal anesthesia. Patients were divided into 4 groups: pethidine, ketorolac, placebo and a combination of ketorolac and pethidine. VAS criterion was used to measure patients' pain.
Results: There was no statistically significant difference between ketorolac, pethidine, placebo and ketorolac + pethidine groups in terms of systolic and diastolic blood pressure and heart rate. Oxygen saturation percentage before and after spinal was significant 15 minutes after surgery (p <0.05). But at other times there was no significant difference (p> 0.05). There was a significant difference in terms of pain in recovery at 6 and 12 hours after surgery (p <0.05). But at other times, the difference was not significant. At 6 hours postoperatively, severe pain was observed in patients in the pethidine and placebo groups and in patients in the ketorolac + pethidine and ketorolac groups; However, at 12 hours postoperatively, severe pain was more common in patients in the pethidine group than in the other groups and was not present in patients in the ketorolac + pethidine group.
Conclusion: The results of this study showed that ketorolac and the combination of ketorolac + pethidine reduce analgesia in patients undergoing orthopedic lower limb surgery.

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medical journal of mashhad university of medical sciences
Volume 67, Issue 2
March and April 2024

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