Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

The effect of a period of high-intensity interval resistance training with vitamin D consumption on the changes in levels of brain-derived neurotrophic factor and malondialdehyde in inactive overweight women

Document Type : Research Paper

Authors
Poorya Abolghasemi 1
Saqqa Farajtabar Behrestaq 2
1 MA of Physical Education, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
2 Assistant Professor, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
10.22038/mjms.2024.79330.4559
Abstract
Introduction: In the last decade, vitamin D has attracted more attention as a non-enzymatic antioxidant compound. The aim of this study was to survey of changes in BDNF and malondialdehyde (MDA) levels after a period of high intensity interval resistance training (HIIRT) and vitamin D intake in inactive overweight women women.
Materials and Methods: The subjects were first selected by the available sampling method, then they were randomly divided into four groups: control, interval exercise, vitamin D, and combined. HIIRT was performed in three sets at intensity with 80% one maximum repetition and 2.5 minutes rest between sets. Vitamin D and combined groups consumed vitamin D (50000 units) once a week. BDNF and MDA levels were measured before and after the interventions.
Results: The findings showed that the MDA levels in the interval exercise, vitamin D and combined groups decreased after 8 weeks and BDNF levels increased significantly. But the combined intervention had a stronger effect on the change of MDA and BDNF levels compared to the other two interventions (p<0.05). In addition, no significant difference was observed between the changes in the levels of interval exercise and vitamin D (P<0.05).
Conclusion: It seems that HIIRT and vitamin D consumption can exert their protective effects in overweight people with abnormal levels of vitamin D, by reducing MDA levels and up-regulation of BDNF protein. But these effects were further developed with combined intervention.
Keywords
Keywords: High-intensity Interval Training
brain-derived neurotrophic factor
malondialdehyde
Vitamin D Deficiency
Subjects
  1. 1. Raharjo S, Pranoto A, Rejeki PS, Harisman ASM, Pamungkas YP, Andiana O. Negative Correlation between Serum Brain-derived Neurotrophic Factor Levels and Obesity Predictor Markers and Inflammation Levels in Females with Obesity. Open Access Maced J Med Sci 2021 [cited 2022 Jan. 26];9(B):1021-6
  2. 2. Wu CL, Chen SD, Yin JH, Hwang CS, Yang DI. Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons. Mol Neurobiol. 2016 Aug;53(6):4126-4142.
  3. 3. Pandit, M, Behl, T, Sachdeva, M, Arora, S. Role of brain derived neurotropic factor in obesity. Obes. Med. 2020;17: 100189.
  4. 4. Roh HT, So WY. The effects of aerobic exercise training on oxidant-antioxidant balance, neurotrophic factor levels, and blood-brain barrier function in obese and non-obese men. J Sport Health Sci. 2017 Dec;6(4):447-453.
  5. 5. Suwa M, Kishimoto H, Nofuji Y, Nakano H, Sasaki H, Radak Z, et al: Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. Metabolism 2006; 55: 852–857.
  6. 6. Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. 2018 Oct;84(10):2194-2207.
  7. 7. Pozzi F, Luigi Aloe, Giovanni Vanni Frajese and Gaetano Frajese.Vitamin D (Calcifediol) Supplementation Modulates NGF and BDNF and Improves Memory Function in Postmenopausal Women: a Pilot Study. Research in Endocrinology 2013;(2013): Article ID 55275.
  8. 8. Corripio R., Gónzalez-Clemente JM, Jacobo PS, Silvia N, Lluis G, Joan V, Assumpta C. Plasma brain-derived neurotrophic factor in prepubertal obese children: Results from a 2-year lifestyle intervention programme. Clin. Endocrinol. 2012;77: 715–720.
  9. 9. Pirotta S, Kidgell DJ, Daly RM. Effects of vitamin D supplementation on neuroplasticity in older adults: a double-blinded, placebo-controlled randomised trial. Osteoporos Int. 2015 Jan;26(1):131-40.
  10. 10. Abiri B, Sarbakhsh P, Vafa M. Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT-1 in obese women with mild to moderate depressive symptoms. Nutr Neurosci. 2021 Jul 2:1-13.
  11. 11. Franco-Robles E, Campos-Cervantes A, Murillo-Ortiz BO, Segovia J, López-Briones S, Vergara P, Pérez-Vázquez V, Solís-Ortiz MS, Ramírez-Emiliano J. Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes. Appl Physiol Nutr Metab. 2014 Feb;39(2):211-8.
  12. 12. Ke CY, Yang FL, Wu WT, Chung CH, Lee RP, Yang WT, Subeq YM, Liao KW. Vitamin D3 reduces tissue damage and oxidative stress caused by exhaustive exercise. Int. J. Med. Sci. 2016;13: 147–153.
  13. 13. Ito F, Sono Y, Ito T. Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: oxidative stress in diabetes, atherosclerosis, and chronic inflammation. Antioxidants. 2019;8(3):72.
  14. 14. Kim TW, Baek KW, Yu HS, Ko IG, Hwang L, Park JJ. High-intensity exercise improves cognitive function and hippocampal brain-derived neurotrophic factor expression in obese mice maintained on high-fat diet. J Exerc Rehabil. 2020 Apr 28;16(2):124-131.
  15. 15. Osali A. Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome. Diabetol Metab Syndr. 2020 Mar 30;12: 26.
  16. 16. Roh HT, Cho SY, So WY. Effects of Regular Taekwondo Intervention on Oxidative Stress Biomarkers and Myokines in Overweight and Obese Adolescents. Int J Environ Res Public Health. 2020 Apr 6;17(7):2505.
  17. 17. Korak JA, Paquette MR, Fuller DK, Caputo JL, Coons JM. Effect of a rest-pause vs. traditional squat on electromyography and lifting volume in trained women. Eur. J. Appl. Physiol. 2018;118: 1309-1314.
  18. 18. Moro T, Marcolin G, Bianco A, Bolzetta F, Berton L, Sergi G, Paoli A. Effects of 6 Weeks of Traditional Resistance Training or High Intensity Interval Resistance Training on Body Composition, Aerobic Power and Strength in Healthy Young Subjects: A Randomized Parallel Trial. Int J Environ Res Public Health. 2020 Jun 8;17(11):4093.
  19. 19. Kalvandi F, Azarbayjani MA, Azizbeigi R, Azizbeigi K. Elastic resistance training is more effective than vitamin D3 supplementation in reducing oxidative stress and strengthen antioxidant enzymes in healthy men. Eur J Clin Nutr. 2022 Apr;76(4):610-615.
  20. 20. Mohebbi H, Safari Mosavi S, Rohani H. The Effect of 12 Weeks Continuous Training at Fatmax Intensity or Anaerobic Threshold, and High Intensity Interval Training on Fat Burning Capacity in Pre-Diabetic Patients. Sport Physiology 2019;11(41):31-46.
  21. 21. Khairy EY, Attia MM. Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF). Nutr Neurosci. 2021 Aug;24(8):650-659.
  22. 22. Uosaee S, Soltani S, Esteghamati A, Motevalian SA, Tehrani-Doost M, Clark CCT, Jazayeri S. Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial. Nutrition. 2020 Mar;71: 110601.
  23. 23. Hajiluian G, Nameni G, Shahabi P, Mesgari-Abbasi M, Sadigh-Eteghad S, Farhangi MA. Vitamin D administration, cognitive function, BBB permeability and neuroinflammatory factors in high-fat diet-induced obese rats. Int J Obes (Lond). 2017 Apr;41(4):639-644.
  24. 24. Filgueiras MS, Rocha NP, Novaes JF, Bressan J. Vitamin D status, oxidative stress, and inflammation in children and adolescents: A systematic review. Crit Rev Food Sci Nutr. 2020;60(4):660-669.
  25. 25. Ahmed HH, El Dayem SMA, Foda FMA, Mohamed HA. Significance of vitamin D in combination with calcium in modulation of depression in the experimental model. Der Pharma Chemica 2015;7: 128-147
  26. 26. Nadimi H, Djazayery A, Javanbakht MH, Dehpour A, Ghaedi E, Derakhshanian H, Mohammadi H, Mousavi SN, Djalali M. Effect of vitamin D supplementation on CREB-TrkB-BDNF pathway in the hippocampus of diabetic rats. Iran J Basic Med Sci. 2020 Jan;23(1):117-123.
  27. 27. Dabaghzadeh F, Rahimpour M, Karami-Mohajeri S. Effect of vitamin D administration on blood oxidative stress factors in university students: A randomized double-blind clinical trial. Koomesh. 2021; 23 (6) :712-719.
  28. 28. Moghadasi M, edalat manesh M A, moeini A, namatollahzadeh M. Effects of eight weeks resistance training on brain derived neurotrophic factor in female patients with multiple sclerosis. Koomesh. 2015; 17 (1) :152-159
  29. 29. Salimi Avansar M. The Effects of Eight Weeks Interval Training and Curcumin Consumption on TNF-α and BDNF Levels in Men with Metabolic Syndrome. J Ardabil Univ Med Sci. 2017; 17 (3) :299-310
  30. 30. Yaghoubi A, elhami A. The Effect of 6 Weeks of High Intensity Circuit Resistance Training on Plasma Level of Brain-Derived Neurotrophic Factor in Inactive Men. Sport Physiology & Management Investigations, 2018; 9(4): 69-78.
  31. 31. Azimi Dokht S, Gharakhanlou R, Naghdi N, Khodadadi D, Zare Zade Mehrizi A. The effect of the treadmill running on genes expression ofthePGC-1α, FNDC5 and BDNF in hippocampus of male rats. Journal of Practical Studies of Biosciences in Sport, 2019; 7(14): 91-101.
  32. 32. Weston KS, Wisløff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med 2014; 48:1227–34.
  33. 33. Batacan RB Jr, Duncan MJ, Dalbo VJ, Tucker PS, Fenning AS. Effects of high-intensity interval training on cardiometabolic health: a systematic review and meta-analysis of intervention studies. Br J Sports Med. 2017 Mar;51(6):494-503.
  34. 34. Tsikas, D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. Anal. Biochem. 2017, 524, 13–30.
  35. 35. Szymczak-Pajor I, Miazek K, Selmi A, Balcerczyk A, Śliwińska A. The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders? Int J Mol Sci. 2022 Jan 16;23(2):956.
Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 3
May and June 2024
Pages 878-888