Document Type : Review article
Authors
1
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2
Department of Microbiology, Urmia University of Medical Sciences, Urmia, Iran
3
Department of Microbiology, Tabriz University of Medical Sciences, Tabriz, Iran
4
Department of Food Science and Technology, Islamic Azad University, Tabriz branch, Tabriz, Iran
5
Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Introduction
The structure of bacteria consists of various macromolecules such as proteins, polysaccharides, phospholipids and nucleic acids, which, in addition to their role in forming their structure, play an essential role in maintaining their viability and pathogenicity. This study aimed to investigate the application of proteomics in the analysis of proteomic profiles of bacteria and their derived postbiotics.
Material and Method
In this review study, relevant data were collected by searching for the keywords "probiotics, postbiotics, proteome, proteomics, biofilm, antibiotic resistance" in the Web of Science, PubMed, Medline, and Scopus databases. All articles related to experimental studies were included in the study and articles that did not contain the full text were excluded.
Results
To study microbial macromolecules, in addition to genomic methods, there are also proteomic methods that provide information about the structural and functional proteins of bacteria. In the scope of bacterial proteomics studies, in addition to pathogenic bacteria, probiotic bacteria are also mentioned, which are part of the structure of this Microorganisms, as well as due to their metabolic activity, produce compounds known as postbiotics, which are responsible for their beneficial effects and have various properties, including antimicrobial, anti-inflammatory and immune system modulating effects.
Conclusion
Utilizing applied proteomics in the field of proteomic profile analysis of bacteria, particularly probiotics can be considered a new approach towards the comprehensive knowledge of postbiotic metabolites, which is the basis for the enrichment of the food matrices for the development of functional foods for health-promoting objectives.
Keywords
Main Subjects
)