Document Type : Research Paper
Authors
1
Assistant Professor of Endocrinology / Endocrine Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2
Associate Professor of Nephrology / Kidney transplantation Complications Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3
Resident of internal Medicine / Kidney transplantation Complications Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4
Full Professor of Nephrology / Nephrology Division, Imam Reza Hospital,Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5
Assistant Professor of Nephrology / Kidney transplantation Complications Research Center, Imam Reza Hospital ,Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Introduction: There is strong clinical and experimental data that testosterone stimulates erythropoiesis. Inflammation, on the other hand, significantly impacts on haemopoiesis, partly through its suppression of erythropoietin and partly through its direct action on erythropoiesis. Therefore, in this study we evaluated correlation of serum testosterone levels with hemoglobin (Hb) and high sensitive CRP (hs-CRP) in patients with Chronic Kidney Disease (CKD (in third and fourth stages and hemodialysis patients.
Materials and Methods: A total of 29 patients with CKD in third and fourth stages (group1) and 29 hemodialysis patients (group 2) were included in this study. Serum hs-CRP, Hb, total and free testosterone, LH, FSH and erythropoietin levels were measured. Pearson`s correlation analysis was used for determining correlation between variables.
Results:The mean of serum hs-CRP level was significantly lower in group1 than group 2, while serum FSH was significantly higher in group1. Pearson`s correlation analysis showed a significant positive correlation between hs-CRP and LH in total patients in two groups and patients in group 2. In comparison among 4 groups including group 1 and 2 with (HgbConclusion: The significant inverse correlation between hs-CRP and total testosterone in hemodialysis patients with Hb lower than 11gr/dl suggested that this association may also partly contribute to anemia in hemodialysis patients compared with CKD patients in third and fourth stages.
Keywords
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