Investigation of Diagnostic Values of hsCRP in Pleural Fluid for Differentiation Tuberculosis and Malignant Pleural Effusion Pulmonary& TB Research Center

Document Type : Research Paper

Authors

1 Associate professor of biochemistry, Mashhad University of Medical Sciences, Mashhad, Iran

2 Assistant professor of pulmonology, Mashhad University of Medical Sciences, Mashhad, Iran

3 Resident of Internal Medicine,Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction
Pleural effusion is one of the most common and important complications in pulmonology. When the absorption of pleural fluid is less than its secretion, effusion happens and diagnosis between TB and malignant pleural fluid is important. C reactive protein with high sensivity(hsCRP) is secreted by tissue when inflammations is present. The aim of this study was hsCRP[S1] evaluation could help to[S2] differentiate between TB and malignant pleural effusion
Materials and Methods
100 patients with TB or Malignant pleural effusion who referred to Emam Reza hospital, Mashhad in 2009 underwent thoracocentesis; then hsCRP with photometry methods were analyzed[S3]. All data were analyzed by SPSS 11 and cutoff point for hsCRP with ROC curve was found.
Result
Mean age was 53.41 years 19.63 SD. Mean concentration of hsCRP was 9.53 (mg/lit) with SD 5.78 (mg/lit). hsCRP concentration in TB group was13.6±5.6 and in malignant pleural effusion group was 6.00±3.93 (mg/lit). They had[S4]significant different with statistical analysis (P<0.001). Sensitivty of hsCRP to differentiate between TB and malignancy with cutoff point of 8.35(mg/lit) is 92% and specificity is 78%. They had significant different with statistical analysis [S5](P<0.001).
Conclusion
hsCRP cloud help us to differentiate between TB and malignant pleural effusion.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 54, Issue 2 - Serial Number 2
May and June 2010
Pages 69-74

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