A Comparison of Serum Level of Selenium in Women with Preeclampsia and Normal Pregnant Women

Document Type : Research Paper

Authors

1 General Physician, Mashhad University of Medical Sciences, Mashhad, Iran

2 Assistant Professor of Gynecology, Mashhad Islamic Azad University, Mashhad, Iran

3 Associated Professor of Gynecology, Mashhad University of Medical Sciences, Mashhad, Iran

4 MPH, Statistics, Mashhad Islamic Azad University, Mashhad, Iran

Abstract

Introduction
Preeclampsia is a common complication of pregnancy with the prevalence of 2-7% which increases fetal-maternal mortality. Despite many researches in this field, the etiology of preeclampsia is still unknown and different theories are suggested. Recently the role of deficiency of trace elements is emphasized. Selenium is one of the trace elements which as an antioxidant play an important role in protection of endothelial cells of blood vessel with counterbalancing of oxygen free radicals. The aim of this study was to compare serum level of selenium in women with preeclampsia and normal pregnant women.
Materials and Methods
This cohort study was performed on 35 women with severe preeclampsia as case group and 30 normal pregnant women as control group in Emam Reza Hospital during 2007-2009. Two groups were matched in terms of maternal age, gestational age, and BMI. Serum level of selenium was measured by spectrophotometer with method of atomic absorption. Data was analyzed with SPSS software version 18 and T-student test. P≤0.05 was considered statistically significant.
Results
The mean serum level of selenium was significantly decreased in preeclamptic women compared to the healthy pregnant women (P<0.05). In preeclampsia group, pregnancy outcomes were worse in women with lower selenium level.
Conclusion
This study showed that severe preeclampsia is related with decreased concentration of selenium; early measurement of this element can be useful for early prediction of preeclampsia.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 54, Issue 2 - Serial Number 2
May and June 2010
Pages 80-85

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