Role of Cytokines in Patients with Arthritis and Low Back Pain Brucellosis Research center of Immunology and Immunology

Document Type : Research Paper

Authors

1 Associate Professor of Immunology Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Professor of Immunology, Mashhad University of Medical Sciences, Mashhad, Iran

3 Associate Professor of Immunology, Mashhad University of Medical Sciences, Mashhad, Iran

4 Infectious Disease Specialist, Mashhad University of Medical Sciences, Mashhad, Iran

5 Intern, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction
Cytokines are secreted as the molecular products of different cells in particular T–Lymphocyte which contribute in the processes of immune responses. Therefore, the study may provide valuable information regarding the function of cell–mediated immunity ( CMI ) in this disease.
.Materials and Methods
This study was performed in the medical centers of Mashhad University of Medical Science. 40 Patients with brucellosis and 40 normal samples took part in this investigation. Diagnosis of the disease was based on case history clinical examination and serological tests.
Results
The levels of TNF-α, IL-2, IFN–γ, IL-4, and IL–10 in serum were measured using ELISA method. The levels of the random variables IL-2 and IL-10 were tested by Kolmogrov Smirnov test and shown to be normal (p<0.05). Other cytokines including IL-4, IFN–γ, and TNF-α of patients serum were not normal. The results indicated that the levels of IL-10 in the sera of patients had increased (p<0.001). IFN–γ level showed it has increased in patients (p<0.05). The level of IL–2 and IL–4 and TNF-α in the sera of patients did not show any appreciable difference with those of normal controls (p>0.1). Kruskal-Wallis test showed a significant difference in IFN–γ in the two groups.
Conclusion
Our results would suggest a definite role of IFN–γ, and IL-10 in sera of patients with arthritis and low bake pain brucellosis.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 53, Issue 3 - Serial Number 3
September and October 2009
Pages 133-137

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