Comparison between efficacy of Tamsulosin and Terazosinin alpha-adrenergic blockers in spontaneous passage of ureter stones after ESWL (A double blind clinical trial)

Document Type : Research Paper

Authors

1 Assistant Professor of Urology, 5 Azar Hospitals, Gorgan, Iran

2 General Practitioner, Gorgan, Iran

3 Epidemiologist, Gorgan, Iran

4 Urologist, Gorgan, Iran

Abstract

Introduction
Nephrolithiasis has a high prevalence in population. Our objective was to compare time of stone passage, severity of pain, frequency of the use of analgesics and the course of disability between groups A, B and C.
Materials and Methods
In this randomized controlled trial study, 240 patients were selected .inclusion criteria was all patient with 5-9mm stone diameter, and exclusion criteria was opium addiction. All of patients were categorized in 3 groups with Block Balance Randomize and double blind method. Each group consisted of 80 persons. In group A (i.e. control group) patients were given daily Diclofenac suppositories of 100mg and Diclofenac tablets of 25mg.In group B patients were given Tamsulosin tablets of 0.4 mg in addition to routine treatment and in group C patients were given Terazosin tablets of 2 mg in addition to routine treatment.
Patients were visited three months after lithotripsy.
Results
The rate of ureteral stone passage in group B (85.5%)was more than group A (80%) and group C (83.3%), the mean expulsion time group A with 14.9 days was more than group B (12.1 days) and group C (12.2 days),also severity of pain on the basis of VAS chart in group B (4.7) less than group A (5.5) and C (5.2), extra analgesic requirement in α blockers group (B:4 patients and C:2 patients) less than control group (8 patients), and all of these were non significantly different
Conclusion
α blockers are decrease symptoms of pain and no effective response on expulsion of stones.

Keywords

References

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medical journal of mashhad university of medical sciences
Volume 52, Issue 2 - Serial Number 2
May and June 2008
Pages 87-94

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