Medical Journal of Mashhad university of Medical Sciences

Medical Journal of Mashhad university of Medical Sciences

The effect of 8 weeks of interval and resistance training on expression PGC 1α,AMPK,TFAM Elderly rat heart cells

Document Type : Research Paper

Authors
Ruhollah Taheri 1
Bahman Mirzaei 2
Arsalan Demirchi 3
1 PhD student in Sports Physiology, Faculty of Physical Education and Sports Sciences, University of Guilan, Rasht, Iran
2 Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran (Corresponding Author)
3 Professor of Sports Physiology, Faculty of Physical Education and Sports Sciences, University of Guilan, Rasht, Iran
10.22038/mjms.2021.19550
Abstract
Introduction: Physiological changes in the cardiovascular system occur gradually with age These changes cause cardiovascular disease, which is a major cause of death in the elderly. The aim of this study was to evaluate the effect of intermittent and resistance training on mitochondrial biogenesis of cardiac myocytes in elderly rats.
Methods: 30 -old rats 23-month weighing 437.2 g were randomly divided into 3 groups: 10, intermittent training (IT), high intensity resistance training (HIRT) and control group (C). Were divided. High-intensity ladder resistance training (80% of MVCC), and intermittent training with 40 to 80% of maximum speed started from the first week and continued with 30 to 110% of maximum speed from the fourth week Exercises were performed for eight weeks and 5 days a week. 72 hours after the last training session, cardiac tissue isolation was performed. Statistical analysis using ANOVA test had a significance level of P ≥ 0.05.
Results: Results The findings of this study showed that aging significantly reduced the expression of AMPK, PGC-1α and TFAM in the heart tissue of elderly rats (P = 0.000). After eight weeks of intervention, the expression of AMPK, PGC-1α, and TFAM increased significantly in both training groups compared to the control group (P = 0.000). Also, there was a significant difference between the training methods on the expression of AMPK, PGC-1α, TFAM (P = 0.000).
Conclusion: The results show that periodicity and resistance improve the expression of proteins associated with mitochondrial biogenesis. Therefore, having regular levels of intermittent and resistance training can be a good solution for favorable changes in cardiovascular risk factors in the elderly.
Keywords
Mitochondrial biogenesis
PGC-1α
‎TFAM
AMPK Resistance and periodic exercises
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Medical Journal of Mashhad university of Medical Sciences
Volume 64, Issue 1
March and April 2021
Pages 2511-2528