Granulomatous inflammation in patients with primary immunodeficiency

Document Type : Review article

Author

department of pediatrics shahid sadoughi university of medical sciences

Abstract

Background and Aim: Granuloma is a delayed type hypersensitivity reaction in response to foreign material. It is manifested by the organized accumulation of mature mononuclear macrophages. Sometimes granuloma may be formed in the absence of external factors. In addition to infectious agents, autoimmune diseases and primary immune deficiencies can cause granuloma. A number of primary immune deficiencies can cause autoimmune disorders and granulomatous inflammation, so these people in addition to frequent infections suffer from non-infectious complications that can have an important effect on prognosis. In this review, we intended to have an overview of primary immunodeficiency diseases with granulomatous inflammation and evaluate the effects of these lesions on the prognosis and course of the disease. Article search was performed by Scopus, Web of Science, and Google Scholar databases. We tried to use the latest and most reliable articles in English and Persian language that are related to our topic. The best articles were selected as references after evaluation of the journal and methodology of the paper.
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Conclusion: Timely diagnosis and treatment of inflammatory conditions, which sometimes appear before infectious manifestations, will be effective in improving the prognosis of the disease. The treatment of these patients with immunosuppressive drugs and corticosteroids should be based on several factors such as: patient's condition, severity of granulomatous inflammation, and presence of active fungal or bacterial infection.

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medical journal of mashhad university of medical sciences
Volume 67, Issue 3
May and June 2024

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