Investigating the effect of pentoxifylline administration on the occurrence of Acute Respiratory Distress Syndrome and some Vital Signs in trauma patients

Document Type : Research Paper

Authors

Assistant Professor, Department of General Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/mjms.2025.83980.4826

Abstract

Objective: Inflammation plays an important role in the pathophysiology of Acute Respiratory Distress Syndrome (ARDS). Due to the mechanisms of effectiveness of Pentoxifylline in inflammatory processes and animal studies that have been performed in this field and because of the lack of human study on the effectiveness of preventive administration of pentoxifylline in patients with ARDS, the present study investigated the effects of preventive administration of pentoxifylline in trauma patients prone to ARDS.
Methods: 62 traumatic patients prone to ARDS who fullified inclusion and exclusion criteria entered the study. These patients triple blind and are randomly devided into treatment group and placebo. The preventive effect of pentoxifylline was investigated on the incidence of Acute respiratory distress syndrome in patients admitted to the Kamyab Hospital in Mashhad. The traetment group received 400 mg of pentoxifylline and the control group received placebo for one week. Before the intervention and during one week some factors were measured such as heart rate, blood pressure, respiration rate, and continuous pulse oximetry, CRP, PO2, PCO2 and PH. Finally, the obtained data were analyzed by SPSS software.
Results: Based on our results, heart rate in treatment group was significantly lower than placebo group (p<0.05). Also, PO2 level was remarkably higher in treatment group (p<0.05). Trend changes on respiratory rate (p>0.05), CRP (p>0.05), PH (p>0.05), PCO2 (p>0.05), respiration rate (p>0.05), HCO3 (p>0.05), Systolic blood pressure (p>0.05) and SPO2 (p>0.05) did not show significant differences between the two groups.

Keywords

References

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Medical Journal of Mashhad university of Medical Sciences
Volume 68, Issue 2
January and February 2025
Pages 185-195

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