The effect of eight weeks of aerobic training with vitamin E supplementation on apoptotic markers in the brain tissue of rates with Parkinson's disease

Document Type : Research Paper

Authors

1 PhD candidate, Department of Sports Science, Na.C., Islamic Azad University, NajafAbad, Iran

2 Department of Sports Science, Na.C., Islamic Azad University, NajafAbad, Iran (Corresponding Author)

3 Department of Sports Science, Na.C., Islamic Azad University, NajafAbad, Iran

10.22038/mjms.2025.85277.4893

Abstract

Introduction: The aim of the present study was to investigate the effect of eight weeks of aerobic training (AT) and vitamin E (VE) supplementation on Bax and Bcl-2 in the brain tissue of rats with Parkinson’s disease.
Methods: In this experimental study, 40 male Sprague-Dawley rats (aged 14–16 months, weighing 250–270 g) with Parkinsonism induced by 2 mg/kg of Reserpine (Res) were divided into five groups: (1) Res, (2) Sham (Sh/Vitamin E solvent), (3) AT, (4) VE, and (5) AT+VE. To evaluate the effects of Res on the variables, 8 healthy rats were placed in the healthy control group (HC). Aerobic training was performed for eight weeks, five sessions per week, 15–48 minutes per session at a speed of 10–24 meters per minute. VE was administered orally at a dose of 30 mg/kg per day. One-way ANOVA and Tukey’s post hoc test were used to analyze the data (P ≤ 0.05).
Findings: In the AT, VE, and AT+VE groups, Bax and Bax/Bcl-2 levels were significantly lower and Bcl-2 levels significantly higher than in the Res group (P = 0.001). Moreover, Bax levels in the VE (P = 0.02) and AT+VE (P = 0.001) groups were significantly lower than in the AT group; Bcl-2 levels in the AT+VE group were significantly higher than in the AT and VE groups (P = 0.001)
Conclusion: It seems that both aerobic training and vitamin E, either individually or combined, play a beneficial role in reducing apoptosis markers in brain tissue under Parkinson’s disease conditions.

Keywords

Main Subjects

References

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Medical Journal of Mashhad university of Medical Sciences
Volume 68, Issue 2
January and February 2025
Pages 416-426

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