Effect of acute and chronic coenzyme Q10 supplementation on lactate dehydrogenase after exhaustive aerobic activity

Document Type : Research Paper

Authors

1 Associate Professor, Department of Sport Sciences, Razi University, Kermanshah, Iran

2 M.A. graduate in Physical Education, specializing in Exercise Physiology and Physical Activity & Health, Razi University, Kermanshah, Iran

Abstract

The aim of present study was investigating the acute and chronic effects of consuming Coenzyme Q10 supplement on rate of lactate dehydrogenase after exhaustive aerobic activity of Bruce. For this purpose 12 out of 22 players of Omid B’esat Kermanshah football team ranging from 19-21 in age volunteered to take part in this study. The study was conducted in 8 weeks and participants were posited into one situation but into two groups of control (N=12) and experimental (N=12). The experimental group during one session (acute effect) in 8 weeks (chronic effect) consumed 200 milligrams of coenzyme Q10 supplement (2 tablets each100 milligrams) daily. In order to exert muscular damage in subjects, they were tested by exhaustion test. Before and after the Bruce test in all three positons of acute, control, and chronic, 5 cc blood was bled from all subjects’ vein head elbow..The activity of serum total lactate dehydrogenase enzyme was determined by the LHD kit of Bio-System Company and auto-analyzer set (Iranian Alfa Classic). All measurements were done form 9-11.5 pm in the same ventilation and light conditions. The results showed that consuming Coenzyme Q10 after exhaustive aerobic activities (Bruce test) caused a significant decrease of inflammatory markers in subjects’ blood’s lactate dehydrogenase in the acute position. But in the chronic position no significant effect of consuming the supplement on decreasing blood’s lactate dehydrogenase was observed.

Keywords

Main Subjects

References

  1. Bloomer RJ, Goldfarb AH, McKenzie MJ.(2006).Oxidative stress response to aerobic exercise: comparison of antioxidant supplements. Med Sci Sports Exerc. 38(6):1098-105.
  2. Dill DB, and Costill DL.(1974).Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol, 37:247-8. Di Renzo L, Galvano F, Orlandi C, Bianchi A, Di Giacomo C, La Fauci L, et al.(2010). Oxidative stress in normal- weight obese syndrome. Obesity. 18(11):2125-30. 
  3. Shults CW, Oakes D, Kieburtz K, et al.(2002).Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the function nal decline. Arch Neurol. 59(10):1541–1550.
  4. Bogdanis G, Stavrinou P, Fatouros I, Philippou A, Chatzinikolaou A, Draganidis D, et al. (2013). Short-term high- intensity interval exercise training attenuates oxidative stress responses and improves antioxidant status in healthy humans. Food Chem Toxicol. 61:171-7.
  5. M, Jafari A, Dehghan Gh.R, Abdizadeh L. (2015). Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners. Med J Islam Repub Iran. Vol. 29: 202.  31. Al-Hasso S. (2000).  Coenzyme Q10: A Review. Hosp Pharm; 35:51–55. 
  6. Bhaskar PA, Raut SE, Hawaldar VB.(2012).The effect ofexercise on platelet aggregagability and other cardiovascular parameters. Inte J of Basic Med Sci. 6(2):27-41. Bill Misner. (1995).Ubiquinone biosynthesis: coenzyme Q-10 impacts health and aerobic metabolism.Ann. Neurol. 38, 357-366. 
  7. Ehrman JK. American College of Sports Medicine.(2010). ACSM'sresource manual for Guidelines for exercise testing and prescription. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; pp 2-84.
  8. Fu X, Ji R, and Dam J.(2010).Antifatigue effect of coenzyme Q10 in mice. J Med Food, 13: 2115.
  9. Kon M, Kimura F, Akimoto T, Tanabe K, Murase Y, Ikemune S, Kono I.(2007). Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. Exerc Immunol Rev; 13:76-88.
  10. Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K.(2008).Reducing exercise- induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Bri J of nutr, 100,903-909.
  11. Shimomura Y, Suzuki M, Sugiyama S, Hanaki Y, and Ozawa T. (1991). Protective effect of coenzyme Q10 on exercise-induced muscular injury. Biochem Biophys Res Commun, 176:349-55. Soares JFP.(2015).Study of the preventive role of physical exercise on mutagenesis: DNA damage and repair mechanisms in human lymphocytes: Effects of physical exercise training. Available from.repositorio.utad.pt/handle/10348/4774. 
  12. Snyder G. James and Jatin, P. Ambegaonkar.(2011).Cryotherapy for treatment of delayed onset muscle soreness. International Journal of Athletic Therapy and Training. 16: 28 – 32.
  13. Aslan R, sekeroglu.M.R, Tarakcioglu M, Bayiroglu F, Meral I. (1996). Effect of acute regular exercise on antioxidative enzymes, tissue damage markers and membrane lipid per oxidation of erytrocytes in sedentary students.Tr.J.of Medi Sci 28,411-414.
  14. Ostman B, Sjödin A, Michaëlsson K, Byberg L.(2012). Coenzyme Q10 supplementation and exercise induced oxidative stress inhumans. Nutrition. 28(4):403-17.
  15. Thirumalai S, Viviyan T, Elumalai E, David P.(2011). Intense and exhaustive exercise induce oxidative stress in skeletal muscle. Asian Pacific Journal of Tropical Disease. 3(12): 63-66.
  16. Cooke M, Iosia M, Buford T, Shelmadine B, et al.(2008). Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 4(2); 5-8.
  17. Deichmann R, Lavie C, and Andrews S.(2010). Coenzyme q10 and statin induced mitochondrial dysfunction. Ochsner J, 10:16-21.
  18. Hofmann P, and Tschakert G.(2011).Special needs to prescribe exercise intensity for scientific studies. Cardiol Res Pract, 2011:209-302.
  19. Moflehi D, Lian YK, Kamalden TF, Amri S. Effect of single-session aerobic exercise with varying intensities on lipid peroxidation and muscledamage markers in sedentary males.
  20. Ceriello A, Bortalotti N, Fulleti E, Tuboga C, Tonutti L, Crescentini A. (1997). Total plasma antioxidant capacity predicts thrombosis prone status in NIDDM patients. Diabetes care. 20(10):1589-1593.
  21. Ceriello A, Bortalotti N, Fulleti E, Tuboga C, Tonutti L, Crescentini A. (1997). Total plasma antioxidant capacity predicts thrombosis prone status in NIDDM patients. Diabetes care. 20(10):1589-1593.
  22. Deichmann R, Lavie C, and Andrews S.(2010). Coenzyme q10 and statin induced mitochondrial dysfunction. Ochsner J, 10:16-21.
  23. Shao AN, Hathcock J.(2006). Risk assessment for creatine monohydrate. Regulatory Toxicology and Phatmacolgy. 45(3):242-251.
  24. Parminder K, Mohinder P. B.(2003). Effect of selenium-induced oxidative stress on the cell kinetics in testis and reproductive ability of male mice. Basic nutritional investigations. Pages 351-357.tness. 2(2):94-98.
Medical Journal of Mashhad university of Medical Sciences
Volume 68, Issue 6
January and February 2026
Pages 1708-1724

Files

Share

How to cite

Statistics