Investigation of the effect of combined training and saffron (Crocus sativus L.) supplementation on serum levels of nitric oxide and erectile function in obese men with type 2 diabetes

Document Type : Research Paper

Authors

1 Assistant Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

2 Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

3 Professor, Department of Exercise Physiology, Faculty of Sports and Health Sciences, University of Tehran, Tehran, Iran.

4 Professor, School of Nutrition and Dietetics, Acadia University, Canada.

Abstract

Introduction: Type 2 diabetes and obesity cause sexual dysfunction in men by reducing vascular function and erectile dysfunction. The aim of the present study was to investigate the independent and interactive effect of 12 weeks of combined training and saffron supplementation on serum levels of nitric oxide and erectile function in obese men with type 2 diabetes.
Materials and Methods: In this quasi-experimental study, 60 obese men with type 2 diabetes (age: 39.51±5.02) were randomly divided into four groups: 1) combined training 2) saffron 3) combined training + saffron 4) control. The subjects of the first and third groups performed a combined training protocol (resistance + aerobics) for 12 weeks. Also, the subjects of the second and third groups received one pill of 100 mg of saffron daily and the first group received the same amount of placebo. Blood samples and related questionnaire were collected in two stages of pre-and post-test to measure the biochemical values and erectile function. Data were analyzed using paired t-test, one-way ANOVA, and Tukey's post hoc test at a significance level of less than 0.05.
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Main Subjects

References

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Medical Journal of Mashhad university of Medical Sciences
Volume 67, Issue 6
January and February 2025
Pages 1525-1537

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