ارتباط بین معیارهای رشد و سطح لیپیدهای سرم با میزان هموگلوبینگلیکه درکودکان و نوجوانان دیابتی

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشیار گروه اطفال، بیمارستان امام رضا (ع)، مشهد، ایران

2 استادیار هماتولوژی، مر کزتحقیقات نوزادان، بیمارستان امام رضا (ع) ، مشهد، ایران

چکیده

مقدمه
دیابت نوع I شایعترین اختلال غددی متابولیکی در کودکان است که بـا عـوارض زیـادی منجملـه اخـتلال رشـد
ممکن است همراه باشد. هدف از این مطالعه بررسی نقش دیابت روی رشد (وزن- قـد)، پارامترهـای رشـد و میـزان
چربیهای خون است.
روش کار
در یک پژوهش مقطعی توصیفی 154 کودک دیابتی از مرداد 85 لغایت تیر 86 از نظـر معیارهـای رشـد وزنـی ،
قدی، طول مدت بیماری، متوسط هموگلوبین گلیکه و لیپیدهای خون مورد ارزیابی قرار گرفتند.
نتایج
متوسط سن تشخیص بیمـاری 6/2 ±3/1 سـال ، سـرعت رشـد قـدی 4/8± 1/48 سـانتیمترو رشـد وزنـی 3±1/5
کیلوگرم در سال بود. بر اساس میزان هموگلـوبین گلیکـه در گـروه کنتـرل متابولیـک خـوب، سـرعت رشـد قـدی
4/8 ±1/3 سانتیمتر، رشد وزنی 3/03±1/6 کیلـوگرم در سـال، کلـسترول تـام برابـر بـا 163/1 ±34، لیپـوپروتئین بـا
چگالی پایین برابر با 109/3 ± 22، لیپوپروتئین با چگالی بالا برابر با 49/5± 1 و تری گلیـسرید برابـر بـا 116/3±55
میلیگرمدر دسی لیتر بود و در گروه با کنترل متابولیک ضعیف، سرعت رشد قدی 3/2±1/22 سانتیمتر و رشد وزنی
3/03 ±1/2 کیلوگرم در سال، کلسترول تام برابر با 172/6±46، لیپوپروتئین بـا چگـالی پـایین برابـر بـا 122/4± 80،
لیپوپروتئین با چگالی بالا برابر با 48/5± 1 و تری گلیسرید برابر با 153/3±105 میلیگرم در دسی لیتر بود . هم چنـین
در گروه با طول بیماری کمتر از 5 سال سرعت رشد قدی 5/7 ± 1/4 سانتیمتر و رشد وزنـی 3/3±1/6 کیلـوگرم در
سال و در گروه با طول مدت بیش از 5 سال سرعت رشد قدی 3/47±1/2 سانتیمتر و رشد وزنی 3/3±1/2 کیلوگرم
در سال بود.
نتیجه گیری
در این مطالعه سرعت رشد وزنی و قدی با کنترل متابولیک ارتباطی نداشت ولیکن اختلال رشد قدی و افـزایش
تری گلیسرید با طول مدت بیماری مرتبط بود. هم چنین دیس لیپدمی با عدم کنترل متابولیک مرتبط بود.

کلیدواژه‌ها


عنوان مقاله [English]

Evaluating the Correlation between HbA1c and Growth Parameters, Lipid Profile in Children and Adolescents with Type 1 Diabetes

نویسندگان [English]

  • Nosrat Ghaemi 1
  • Mahmoud Keramati 2
  • Rahim Vakili 1
1 Associate professor ofPediatrics diseases, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2 Assistant Professor of Hematopathology, Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Introduction
Type1 diabetes is the most common endocrine disorder in children. The disease is associated with a variety of complications including growth abnormalities. The aim of this study was to evaluate the role of diabetes and blood sugar control on physical growth (height and weight), growth parameters and lipid profile.
Materials and Methods
This descriptive cross- sectional study took place from July 2006 to July 2007. A total of 154 children and adolescents with diabetes type 1, evaluated for their growth parameters, lipid profile٫ and its correlation with duration of diabetes and mean HbA1C.
Results
The mean age of diabetes diagnosis recorded 6.2±3.1 year. The mean height growth velocity was 4.8±1.48 cm and the mean weight growth velocity 3±1.5 kg in one year. In the first group with HbA1c< 8 (mean±1sd) height and weight growth velocities were 4.8±1.3 cm and 3.03±1.6 kg in a year respectively. In the second group with HbA1c > 8 (mean±1SD), yearly height and weight growth velocities measured 3.2±1.22 cm and 3.03±1.2 kg in turn. Moreover, in the first group TC, LDL, HDL and TG were 163.1±34 mg/dl, 109.3±22 mg/dl, 49.5±1 mg/dl, 116.3±55 mg/dl and in the second group 172.6±46 mg/dl, 122.4±80 mg/dl, 48.5±1 mg/dl, 153.3±1.5 mg/dl in the order mentioned. In the group with disease duration less than 5 years, height and weight growth velocities were 5.7±1.4 cm and 3.3±1.6 kg and in group with disease duration more than 5 years, height and weight velocities reported 3.74±1.2 cm and 3.3±1.2 kg annually respectively.
Conclusion
According to this study, there was no correlation between the mean of height, weight growth velocities and metabolic control in both groups. However, the hight growth disorder and increase in the level of TG were correlated with the duration of disease. Also, lipid profile (dislipidemia) was associated with the lack of metabolic control.

کلیدواژه‌ها [English]

  • Iddm
  • Height
  • Weight
  • HbA1c
  • Lipid
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