گزارش یک مورد هیستیوسیتوزسینوزال با لنفادنوپاتی ماسیو (بیماری روزائی- دورفمن)

نوع مقاله: گزارش مورد

نویسندگان

1 استادیار پاتولوژی

2 استادیار جراحی اطفال

3 استادیار اطفال

4 رزیدنت پاتولوژی

چکیده

هیستیوسیتوزسینوزال با لنفادنوپاتی ماسیو (بیماری روزائی- دورفمن)، یک بیماری نادر خوش خیم هیستیوسیتی با علت ناشناخته بوده، که به طور معمول با
بزرگی غدد لنفاوی سطحی و عمقی همراه است. بیماری معمولا سیر بالینی طولانی داشته و با دوره های متناوب از تشدید و فروکش علائم، توام است.
در این مقاله یک مورد از بیماری روزائی- دورفمن در پسر 5 ساله، با لنفادنوپاتی حجیم ناحیه اینگوینال راست، لنفادنوپاتی گردنی، تب گاهگاهی و کم خونی
گزارش گردیده است و نشانه های بالینی، ویژگی های هیستوپاتولوژیک و درمان آن، مورد بحث قرار گرفت.
 

کلیدواژه‌ها


عنوان مقاله [English]

Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease): A Case Report

نویسندگان [English]

  • N Zabolinejad 1
  • M. Hiradfar 2
  • Z Badiee 3
  • N Ghaemi 3
  • A. Attaranzadeh 4
چکیده [English]

Introduction: Sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease (RDD) is a rare benign histiocytic disease of unknown etiology, usually associated with lymph node enlargement in various superficial or deep sites.
It usually shows a prolonged clinical course with occasional exacerbation and remission phases.
In this article case of RDD in a 5-year-old male with large right inguinal and bilateral cervical lymphadenopathies were, occasional fever and anemia was described. The clinical presentation, histopathologic characteristics, and treatments of RDD were discussed.

1- Rosai J, Dorfman R.F. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign
clinicopathological entity. Arc Pathol 1969; 87:63-70.
2- EI Kohen A, Planquart X, AL Hamany Z, et al. Sinus histiocytosis with massive lymphadenopathy (RosaiDorfman
Disease): two case reports. Int J Pediatr Otorhinolaryngol 2001; 61(3): 243-7.
3- Ioachim Harry L, Ratech H. Ioachim’s lymph node pathology. 3rd ed. Philadelphia: Lippincott. 2002; 212-216.
4- Maric I, Pittaluga S, Dale J, et al. Histologic features of sinus histocytosis with massive lymphodenopathy in
patients with autoimmune lymphoproliferative syndrome. Am J Surg Pathol 2005; 29(7): 903-911.
5- Iwabuchi H, Kakihara T, Tanaka A, et al. Congenital Rosai-Dorfman disease without lymphadenopathy. Pediatr
Pathol Mol Med 2003; 22(5): 399-403.
6- Sodhi KS, Suri S, Nighawan R, et al. Rosai-Dorfman disease. Unusual cause of diffuse and massive
retroperitoneal lymphadenopathy. Br J Radiol 2005; 78(933): 845-7.
7- Meyer CH, Sel S, Horle S, et al. Rosai-Dorfman disease with bilateral serous retinal detachment. Arch
Ophthalmol 2003; 121(5): 733-5.
8- Reddy A, Beigi B, Linardos E. Rosai-Dorfman Syndrome affecting the lacrimal gland. Orbit 2001; 20(3): 239-
242.
9- Khan K, Moriarty P, Kennedy S. Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy of
the orbit Br J Ophthalmol 2003; 87(8):1054.
10- Hagemann M, Zbaren P, Stauffer E, Caversaccio M. Nasal and paranasal sinus manifestation of Rasai-Dorfman
disease. Rhinology 2005; 43 (3): 229-32.
11- Ohori NP. Yu J, Ladreneau RJ, Thaete FL, Kane K. Rosai-Dorfman disease of the pleura: a rare extranodal
presentation. Hum Pathol. 2003; 34(11):1210-1.
12- Anders RA, Keith JN, Hart J. Rosai-Dorfman disease presenting in the gastrointestinal tract. Arch Pathol Lab
Med 2003; 127(2): E74-5.
13- Lauwers GY, Perez-Atayde A, Dorfman RF, Rosai J. The digestive system manifestations of Rosai-Dorfman
disease (sinus histiocytosis with massive lymphadenopathy): review of 11 cases. Hum Pathol 2000; 31(3): 380-5.
14- George J, Stacy G, Peabody T, Montag A. Rosai-Dorfman disease manifesting as a solitary lesion of the radius
in a 41-year-old woman. Skeletal Radiol 2003; 32(4):236-9.
15- Oritz-Hidalgo C, Cuesta-Mejias TC, Ochoa-Ochoa C, et al. Rosai-Dorfman disease limited to the skin. Four
case reports. Gac Med Mex 2003; 139(1):1-6.
16- Powell JG, Goellner JR, Nowak LE, McIver B. Rosai-Dorfman Disease of the thyroid masquerading as
anaplastic carcinoma. Thyroid 2003; 13(2): 217-21.
17- Sato A. Sakurada K, Sonoda Y, et al. Rosai-Dorfman disease presenting with multiple intracranial and
intraspinal masses: a case report. No Shinkei Geka 2003; 31(11): 1199-204
18- Rodriguez-Galinda C, Helton KJ, Sanchez ND, et al. Extranodal Rosai-Dorfman disease in children. J Pediatr
Hematol Oncol 2004; 26(1): 19-24.
19- Kaur PP, Birbe RC, DeHoratius RJ. Rosai-Dorfman disease in a patient with systemic lupus erythematosus. J
Rheumatol 2005; 32(5): 951-3.
20- Lopes LF, Bacchi MM, Coelho KI, et al. Emperiopolesis in a case of B-cell lymphoma: a rare phenomenon
outside of Rosai-Dorfman Disease. Ann Diagn Pathol 2003; 7(5): 310-3.
21- Shoda H, Oka T, Inoue M, et al. Sinus histiocytosis with massive lymphadenopathy associated with malignant
lymphoma. Intern Med 2004; 43 (8): 741-5.
22- Pulsoni A, Anghel G, Falcucci P, et al. Treatment of the sinus histiocytosis with massive lymphadenopathy
(Rosai-Dorfman Disease): report of a case and literature review. Am J Hematol 2002; 69(1): 67-71.