نوع مقاله : مقاله پژوهشی
نویسندگان
1 مرکز علوم و اعصاب اصفهان، مرکز تحقیقات الزهرا، دانشگاه علوم پزشکی اصفهان، ایران.
2 گروه جراحی اعصاب دانشگاه علوم پزشکی اصفهان
3 آزمایشگاه ژنتیک پزشکی، بیمارستان الزهرا، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.
4 گروه جراحی اعصاب، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.
5 گروه مهندسی بافت و ترمیم، دانشکده فناوری های نوین در پزشکی، دانشگاه شهید بهشتی، تهران، ایران.
6 گروه جراحی اعصاب، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
چکیده
کلیدواژه‌ها
عنوان مقاله [English]
نویسندگان [English]
Background: Lumbar disc herniation (LDH) is a multifactorial degenerative disease is affected by genetic inheritance and environmental factors. Type XI collagen is important for organization of the extracellular matrix and cartilage collagen construction. Expression of the COL11A1 can be modified by rs1676486 that C-T transition mediating LDH susceptibility. Expression of the COL11A1 transcript reduced by T-allele of rs1676486.
Material and methods: rs1676486 of COL11A1 was genotyped in 100 patients and 100 healthy controls. HRM (High resolution melting) Assay used for genotyping of SNP rs1676486 of COL11A1. χ2 and fisher test were evaluated to differences of genotype and allele distributions between LDH patients and healthy controls. To compare the relationship between genotypes and clinical features was used Mann Whitney test.
Result:This study showed, rs1676486 in COL11A1 gene was associated with modified LDH at age ≤50 years’ and gene increased LDH risk at age >50 years. SNP rs1676486 had the significant association with lumbar disc herniation (P=0.019), and patients were found to have higher frequency of AA than the controls.
Conclusion: This observation shows that type XI collagen is related to age and genetic factor in LDH disease.
کلیدواژه‌ها [English]
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