نوع مقاله : مقاله پژوهشی
1 گروه فیزیولوژی ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران.
2 گروه فیزیولوژی ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران. (نویسنده مسئول)
عنوان مقاله [English]
Background: Consumption of fried foods and heated oils is spreading rapidly, which has become a nutritional problem in today's society. This study aimed to determine the effect of a course of aerobic training and octopamine supplementation on the expression of DRP, MFN-1, and cytochrome C genes in the heart muscle of rats fed with deep-fried oils.
Material and Methods: thirty 8-week-old Wistar rats with an average weight of 200 to 250 g were randomly divided into 5 groups (6 each) including healthy control (C), consumption of deep-fried oils (DFO), consumption of deep-fried oils + exercise aerobics (DFO+T), Deep Fried Oils Consumption + Octapamine Supplement (DFO+O), Deep Fried Oils Consumption + Aerobic Exercise + Octapamine Supplement (DFO+TO). During the study period, deep heated oils were fed orally (gavage, 10 ml/kg) to the rats for 4 weeks. 81 µmol/kg octopamine was injected intraperitoneally into the supplement groups. Rats in the exercise training group also trained on a moderate-intensity treadmill of 50% vo2max in the first week and 65% vo2max in the last week.
Results: The expression of DRP and cytochrome C genes increased due to oil consumption and decreased due to exercise and octopamine supplementation. Also, the lowest DRP and cytochrome C gene expression was observed in the DFO+TO group. Consumption of deep heated oil significantly reduced the concentration of MFN-1 and aerobic exercise and concomitant use of octopamine supplementation increased the expression of the MFN-1 gene compared to other groups. The interaction effect of the two variables of exercise and supplementation was not significant.
Conclusion: It is possible that aerobic exercise + octopamine in combination can modify the destructive effects of deeply heated oils on the mechanism of myocardial dynamics of the heart muscle by modulating the DRP, MFN-1, and cytochrome C genes.