نوع مقاله : مقاله پژوهشی
1 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه صنعتی شاهرود، شاهرود، ایران
2 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه صنعتی شاهرود، سمنان، ایران
3 گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه دامغان، دامغان، ایران
عنوان مقاله [English]
Introduction: Diabetes with high blood sugar can cause central nervous system disorders. Consumption of stevia and vanadium are effective in regulating blood sugar, and may be associated with endurance activity in the brain tissue of diabetic rats.
Materials and Methods: The 35 male rats (180±10 g) (6-8w age) after 4 weeks of high-fat diet (70 g/kg daily), were divided into 7 groups: 1.control, 2.diabetic, 3.diabetic+exercise, 4.diabetic+vanadium, 5.diabetic+stevia, 6. diabetic+exercise+vanadium, 7.diabetic+exercise+stevia. To induce type1 diabetes, streptozotocin (55mg/kg) was injected intraperitoneally, and vanadium extract (1mg/ml) was dissolved in water daily. The endurance training consisted of eight weeks, five days a week, starting at 15 minutes at 20 meters/minute and ending at 35 minutes at 30 meters/minute. Histopathological changes in brain tissue were examined using a light microscope. In order to normalize the parametric data, Kolmogorov-Smirnov test and for their analysis, one-way ANOVA with Bonferroni post hoc test, and for non-parametric data, Kruskal-Wallis test (p≤0.05) was used.
Results: Body weight decreased significantly in all six experimental groups compared to healthy control group (p=0.001), in vanadium group compared to vanadium+exercise (p=0.01), and in stevia+exercise group compared to stevia (p=0.04). In the diabetic group, mild neuronal changes improved with exercise, stevia consumption and exercise + stevia, and mild hyperemia, with exercise, vanadium consumption, and exercise+vanadium (p=0.001).
Conclusion: Eight weeks of endurance exercise, stevia and vanadium intake appear to be effective in regulating body weight as well as improving the brain damage caused by diabetes.