نوع مقاله : مقاله پژوهشی
1 کارشناس ارشد فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد ساوه، ساوه، ایران
2 استادیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد ساوه، ساوه، ایران (نویسنده مسئول)
3 استادیار مدیریت ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد ساوه، ساوه، ایران
عنوان مقاله [English]
Introduction: FoxO1 is a transcription factor involved in energy metabolism, which contributes to the pathology of metabolic disorders, including obesity and diabetes. The purpose of this study was to investigate the effect of six weeks of high intensity interval training (HIIT) on FoxO1 gene expression in subcutaneous adipose tissue and lipid profile of high fat diet-induced obese male rats.
Methods: In this experimental study, fourteen male Wistar rats were fed a high-fat diet for six weeks, then were randomly divided into training (n=7) and control (n=7) groups. The training group performed the HIIT protocol on a treadmill for six weeks. FoxO1gene expression in subcutaneous adipose tissue and lipid profile were measured after the last training session. Data were analyzed by independent T test.
Results: There was no significant difference in the FoxO1 gene expression between the two groups after interval training (P>0.05). The levels of cholesterol and high-density lipoprotein were significantly lower and higher respectively in the training group compared to the control group (P˂0.05). No significant difference was found in triglycerid and low-density lipoprotein levels between the two groups (P˃0.05).
Conclusion: It seems that six weeks of HIIT in obese rats can improve the lipid profile without changing FoxO1 gene expression in subcutaneous adipose tissue.