نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجوی دکتری، مرکز تحقیقات طب ورزشی، واحد نجفآباد، دانشگاه آزاد اسلامی، نجفآباد، ایران
2 استادیار، مرکز تحقیقات طب ورزشی، واحد نجفآباد، دانشگاه آزاد اسلامی، نجفآباد، ایران (نویسنده مسئول)
3 استادیار، مرکز تحقیقات طب ورزشی، واحد نجفآباد، دانشگاه آزاد اسلامی، نجفآباد، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Introduction: Obesity leads to the occurrence of various diseases such as cardiovascular diseases, which physical exercise can mitigate. The aim of the current study was to investigate the changes in certain genes influencing cardiac muscle angiogenesis following eight weeks of endurance and resistance exercises in obese male Wistar rats.
Methods: The method of experimental research was pre-test, post-test and experimental and control groups. Twenty-four obese Wistar male rats, aged eight weeks with a weight of 356.61 ± 34.00 grams, were randomly divided into three groups: endurance (n=8), resistance (n=8), and control (n=8). The experimental groups underwent five sessions per week of endurance exercises at 70-80% maximum speed intensity and resistance exercises at 50-120% body weight intensity over an eight-week period. Real-Time PCR was used to measure gene expression, and Western blotting was employed to measure protein levels. One-tailed analysis of variance (ANOVA) and Tukey's post hoc test were used to determine significant differences between groups at a significance level of P ≤ 0.05.
Findings: The data indicated that both endurance and resistance exercises significantly increased the expression of Piezo1 gene (P = 0.001), Yoda1 gene (P = 0.001), and the levels of FSTL-1 protein (P = 0.001) and NFDF protein (P = 0.001) compared to the control group. However, no significant differences were observed between the experimental groups (P > 0.05).
Conclusion: Based on the results of this study, endurance and resistance exercises appear to be effective in modulating certain factors involved in reducing obesity-related complications.
کلیدواژهها [English]