ارتباط بین مصرف مس و منیزیم با بیماری های قلبی عروقی: مقاله مروری

نوع مقاله : مقاله مروری

نویسندگان

1 مرکز تحقیقات سندرم متابولیک، دانشگاه علوم پزشکی مشهد، مشهد، ایران; مرکز بین المللی یونسکو علوم پایه مرتبط با سلامت و تغذیه انسان، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 مرکز تحقیقات سندرم متابولیک، دانشگاه علوم پزشکی مشهد، مشهد، ایران; گروه ژنتیک پزشکی و پزشکی مولکولی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران; مرکز تحقیقات جراحی آندوسکوپی و کم تهاجمی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

چکیده

بیماریهای قلبی-عروقی (CVD) یکی از علل اصلی مرگ و میر هستند. مطالعات متعددی بر ارتباط بین مصرف مس و CVD در مطالعات اپیدمیولوژیک تمرکز کرده‌اند. با این حال، اثرات مس خوراکی در CVD همچنان مورد بحث است. تعدادی از مطالعات روی مدل حیوانی مشاهده کردند که مصرف مس بر اساس مسیرهای مولکولی ارتباط قوی با آتروژنز دارد. با این حال سایر مطالعات این هم‌بستگی را تایید نکرده‌اند. کارآزمایی‌های بالینی ارتباطی بین مصرف مس با CVD نشان نداده‌اند و مقدار مصرف بهینه مس برای کاهش خطر ابتلا به CVD ها نامشخص است. منیزیم (Mg) عنصر حیاتی دیگری است که در فرآیندهای مختلف زیستی نقش اساسی دارد. چندین کارآزمایی تصادفی‌شده شاهد‌دار (RCT) و فراتحلیل ها گزارش کرده‌اند که افرادی که مصرف بالای منیزیم دارند، کمتر در معرض خطر برای ابتلا به CVD هستند. بر اساس مشاهدات، افزایش مصرف منیزیم خطر ابتلا به عوامل خطر نارسایی قلب (CD) و CVD را کاهش میدهد. این مطالعه همچنین نشان داد که افراد با مصرف بالای منیزیم نیز کمتر در معرض خطر ابتلا به فشار خون و بیماری قند هستند. هدف این بررسی مرور یافته‌های اخیر در مورد ارتباط بین مصرف مس و منیزیم و بیماری‌های قلبی عروقی است. علاوه بر این، مطالعات RCT دقیق تری برای درک کامل مکانیسم های اساسی و درگیر در اثرگذاری منیزیم بر سلامت قلب و عروق مورد نیاز است.

کلیدواژه‌ها

عنوان مقاله [English]

Association between Copper and Magnesium Intake with Cardiovascular Disease: A Narrative Review

نویسندگان [English]

  • Sara Saffar Soflaei 1
  • Maryam Saberi-Karimian 2
1 MD-PhD, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; saberiInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran,
2 PhD, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality. Various studies have focused on the association between copper intake and CVD in epidemiological studies; however, the effects of dietary copper in CVD remains controversial. Some animal model studies have observed a strong association between copper intake and atherogenesis based on molecular pathways, while other studies were unable to confirm this correlation. Clinical trials have not demonstrated a clear link between copper intake and CVD, and the optimal copper intake to reduce the risk of developing CVDs remain unclear. Magnesium is another crucial element that plays essential roles in various biological processes. Several randomized controlled trials (RCTs) and meta-analyses have reported that individuals with high magnesium intake have a lower risk of developing CVD. It has been observed that increased magnesium intake reduces the risk of CVD risk factors and CVD. The study also indicated that individuals with high magnesium intake have a lower risk of developing hypertension and diabetes. The purpose of this review is to summarize recent findings on the link between copper and magnesium intake and CVD. Furthermore, more thorough RCTs are required to fully understand the underlying mechanisms involved in the effect of magnesium on cardiovascular health.

کلیدواژه‌ها [English]

  • Copper
  • Magnesium
  • Cardiovascular disease

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مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 67، شماره 6
بهمن-اسفند1403
بهمن و اسفند 1403
صفحه 1700-1711

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