بررسی شیوع دیس لیپیدمی در گروه های مختلف چاقی در جمعیت کوهورت ‏فسا

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه علوم تشریحی، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران

2 گروه مهندسی بافت، دانشکده پزشکی، دانشگاه علوم پزشکی فسا، فسا، ایران

3 کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی فسا، فسا، ایران

4 مرکز تحقیقات جراحی عروق و اندوواسکولار، دانشگاه علوم پزشکی مشهد، مشهد، ایران

5 مرکز تحقیقات سندرم متابولیک، دانشگاه علوم پزشکی مشهد، مشهد، ایران

6 مرکز تحقیقات بیماری‌های غیرواگیر، دانشگاه علوم پزشکی فسا، فسا، ایران

10.22038/mjms.2025.80075.4621

چکیده

مقدمه: چاقی و دیس لیپیدمی از عوامل اصلی خطر در بیماری های قلبی عروقی (‏CVD‏) محسوب می شوند. هدف از این مطالعه بررسی شیوع دیس لیپیدمی در گروه ‏های مختلف چاقی در جمعیت کوهورت بزرگسالان فسا است.‏
روش کار: در این مطالعه مقطعی توصیفی-تحلیلی، 10118 شرکت کننده 35 تا 70 ساله، از نظر ابتلا به چاقی و سندرم متابولیک به هشت گروه تقسیم شدند: ‏BMI‏ نرمال، ‏BMI=25-29/9‎، ‏BMI=30-34/9‎، ‏BMI≥35‎‏ (هر کدام با سندرم متابولیک منفی یا مثبت). شیوع دیس لیپیدمی در گروههای مختلف چاقی بررسی ‏شد و معنیداری با آزمونهای کای اسکوئر، آنالیز واریانس یکطرفه بررسی شد. جهت بررسی اثر هر یک از متغیرها بر سندرم متابولیک از رگرسیون لجستیک استفاده شد. ‏معنی داری در سطح 05/0 در نظر گرفته شد و از نرم افزار ‏SPSS‏ برای آنالیز داده ها استفاده شد.‏
نتایج: . نتایج نشان داد فراوانی افراد دارای دیس لیپیدمی با ‏BMI=25-29/9‎، 8/87 ‏‎%‎، ‏BMI=30-34/9‎، 1/89 ‏‎%‎، ‏BMI≥35‎، 5/91 % است. در افراد مبتلا ‏به سندرم متابولیک در همه گروه های ‏BMI، فراوانی افراد دارای دیس لیپیدمی بالاتر از افراد فاقد دیس لیپیدمی است. همچنین شانس ابتلا به دیس لیپیدمی در افراد مبتلا به ‏سندرم متابولیک در گروههای چاقی 9/29-25، 1/45 % و 9/34-30، 4/67 % بیشتر از افراد سالم بود. ‏
بحث و نتیجه گیری: نتایج نشان می دهد شیوع دیس لیپیدمی در جمعیت کوهورت بزرگسالان فسا بالاست که با توجه به بالا بودن ریسک عوارض و بار مالی ناشی ‏از این بیماری، توجه به سیاست گذاری برای کاهش دیس لیپیدمی از اهمیت فراوانی برخوردار است.‏

کلیدواژه‌ها


عنوان مقاله [English]

Investigating the prevalence of dyslipidemia in different obesity groups in the Fasa cohort ‎population

نویسندگان [English]

  • Mohammad Ebrahim Astaneh‎ 1 2 3
  • Susan Darroudi 3 4 5
  • Farshad Rastiyan Nasab 3
  • Narges Fereydouni 6
1 Department of Anatomical Sciences, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
2 Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
3 Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
4 Vascular and endovascular surgery research center, Mashhad University of Medical Sciences, Mashhad, Iran
5 Metabolic syndrome research center, Mashhad University of Medical Sciences, Mashhad, Iran
6 Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
چکیده [English]

Introduction: Obesity and dyslipidemia are critical risk factors for cardiovascular diseases (CVD). ‎This study aims to assess the prevalence of dyslipidemia across various obesity categories in the adult ‎population of the Fasa cohort. ‎
Methodology: Utilizing a descriptive-analytical, cross-sectional design, the study sampled 10,118 ‎participants aged 35 to 70, categorized into eight groups based on BMI and metabolic syndrome status: ‎normal BMI, BMI 25-29.9, BMI 30-34.9, and BMI ≥35, each further divided by the presence or ‎absence of metabolic syndrome. Dyslipidemia prevalence was evaluated across these groups using chi-‎square tests and one-way ANOVA, while logistic regression analyzed the impact of each variable on ‎metabolic syndrome. Statistical significance was set at a 0.05 threshold, with SPSS software facilitating ‎data analysis. ‎
Results: The findings revealed dyslipidemia prevalence rates of 87.8% for BMI 25-29.9, 89.1% for ‎BMI 30-34.9, and 91.5% for BMI ≥35. Individuals with metabolic syndrome exhibited higher ‎dyslipidemia prevalence across all BMI groups compared to those without metabolic syndrome. ‎Additionally, the odds of having dyslipidemia in those with metabolic syndrome were 45.1% higher in ‎the BMI 25-29.9 group and 67.4% higher in the BMI 30-34.9 group than in healthy individuals. ‎
Discussion and conclusion: The high prevalence of dyslipidemia in this population underscores the ‎need for targeted policy interventions to mitigate the associated health risks and financial burdens.‎

کلیدواژه‌ها [English]

  • Obesity
  • Metabolic syndrome
  • Dyslipidemia
  • Cholesterol
  • Triglyceride
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