مقایسه اثرات ورزش هوازی و سایلوسایبین بر تغییرات هیستوپاتولوژی ناشی از مت آمفتامین در تخمدان موش‌های صحرایی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه پزشکی، کمیته تحقیقات دانشجویی، دانشکده علوم پزشکی، دانشگاه آزاد اسلامی شاهرود، شاهرود، ایران

2 دانشجوی پزشکی، کمیته تحقیقات دانشجویی، واحد شاهرود، دانشگاه آزاد اسلامی، شاهرود، ایران

3 گروه پزشکی، واحد شاهرود، دانشگاه آزاد اسلامی، شاهرود، ایران

10.22038/mjms.2024.77412.4504

چکیده

مقدمه :متامفتامین (METH) نوعی داروی روانگردان اعتیادآور است که مصرف مکرر آن باعث آسیب به سیستم عصبی مرکزی و اندام های مختلف بدن می شود. با توجه به افزایش مصرف روز افزون متامفتامین در زنان و اثرات مخرب آن بر سیستم تولید مثل به خصوص تخمدان ها بر آن شدیم که در این مطالعه اثرات ناشی از مصرف متامفتامین و سایلوسایبین که یک ترکیب روانگردان درون قارچ های توهم زا می باشد و انجام ورزش هوازی را بر بافت تخمدان موش های صحرایی بررسی کنیم.
روش کار: در این مطالعه تجربی آزمایشگاهی از چهل راس موش صحرایی استفاده گردید که در پنج گروه هشت تایی کنترل، مت آمفتامین، مت آمفتامین و ورزش هوازی، مت آمفتامین و سایلوسایبین و گروه هر سه تایی تقسیم شدند. پس از مواجهه یافته های پژوهش بصورت کیفی بصری توسط میکروسکوپ نوری مورد ارزیابی قرار گرفتند.
نتایج: در گروه متامفتامین شاهد کاهش تعداد سلول های بافت تخمدان و از بین رفتن نظم و انسجام بافت ها و همچنین نازک شدن یا عدم تشکیل لایه ی تکا هستیم. در گروه همراه با ورزش این تغییرات محدود به کاهش تعداد سلول ها و تغییرات مختصر در استرومای تخمدان می باشد. در گروه همراه سایلوسایبین فولیکول های ثانویه و اووسیت ها کاهش یافته و لایه تکا نازک است و شواهد اتساع عروقی و پرخونی دیده شد.
نتیجه گیری: ورزش تغییرات بافت شناسی ناشی از متامفتامین را تخفیف داده است اما اثرات محافظتی سایلوسایبین در مقایسه با ورزش چشمگیر نبوده است.

کلیدواژه‌ها

عنوان مقاله [English]

Comparing the effects of aerobic exercise and psilocybin on the histopathological changes caused by methamphetamine in the ovaries of rats

نویسندگان [English]

  • Hessamedin Babaei 1
  • Mohammad Asghari Haghverdi 2
  • Mahnaz Nouri 3
  • Soheil Shahrami rad 2
  • Behrooz Yahyaei 3
1 Student Research Committee, Shahrood Branch, Islamic Azad University, Shahrood, Iran
2 Student Research Committee, Shahrood Branch, Islamic Azad University, Shahrood, Iran
3 Department of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran
چکیده [English]

Introduction: Methamphetamine that is a highly addictive psychoactive substance that has been found to have detrimental effects on the central nervous system and various organs within the human body. Our research aims to explore the impact of methamphetamine, as well as psilocybin (a psychoactive compound found in hallucinogenic fungi), and aerobic exercise on the ovarian tissue of rats.
Materials and Methods: This laboratory experimental study involved the utilization of a total of forty rats, which were allocated into five distinct groups consisting of eight rats each. These groups were categorized as follows: control group, methamphetamine group, methamphetamine group with aerobic exercise, methamphetamine group with psilocybin, and methamphetamine group with exercise and psilocybin. Following the completion of the research investigations, a qualitative visual evaluation was conducted using an optical microscope.
Results: Within the methamphetamine group, a notable decline in the quantity of ovarian tissue cells was observed, accompanied by the disruption of tissue organization and cohesion, as well as the occurrence of thinning or absence of the theca layer. Conversely, in the exercise group, a decrease in cell count and alterations in the ovarian stroma were observed. In the psilocybin group, a reduction in secondary follicles and oocytes was observed, along with thinning of the theca layer, and evidence of localized dilatation and hyperemia.
Conclusion: The implementation of exercise demonstrated a reduction in the histological alterations induced by methamphetamine. However, it is worth noting that the protective effects of psilocybin were comparatively less pronounced when compared to the effects of exercise.

کلیدواژه‌ها [English]

  • Methamphetamine
  • Psilocybin
  • aerobic exercise
  • ovarian tissue
  • rats

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مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 68، شماره 2
خرداد-تیر1404
خرداد و تیر 1404
صفحه 259-269

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