اثر 12 هفته تمرینات ترکیبی بر هموسیستئین سرم و پپتید ناتریورتیک مغزی (NT-proBNP) در بیماران قلبی-عروقی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی ، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد تهران جنوب،ایران

2 دانشیار، گروه فیزیولوژی ورزشی، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه آزادواحد تهران جنوب، ایران (نویسنده مسئول)

3 استادیار ، گروه فیزیولوژی ورزشی، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه آزادواحد زنجان، ایران

4 دانشیار، گروه فیزیولوژی ورزشی، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه آزادواحد تهران جنوب، ایران

5 استادیار، گروه فیزیولوژی ورزشی، دانشگاه آزاداسلامی واحد پرند، ایران

10.22038/mjms.2025.26204

چکیده

مقدمه: کم تحرکی ، زمینه ساز بسیارى از بیمارى ها از جمله بیمارى هاى قلبی- عروقی است .امروزه تغییر سبک زندگی و به تبع آن بیماریهای قلبی- عروقی یکی از علل شایع مرگ و میردر جهان است.  هدف از مطالعه حاضر، تعیین اثر تمرین ترکیبی (هوازی و مقاومتی)  بر سطوح هموسیستئین (Homocysteine) و پپتید ناتریورتیک مغزی (N-terminal proBrain Natriuretic Pepted) بر بیماران قلبی عروقی می باشد.
روش کار: در این پژوهش که با طرح پیش آزمون و پس آزمون همراه با گروه کنترل انجام شد، 24بیمار داوطلب به طور تصادفی در 2 گروه تمرین ترکیبی (12 نفر)  وکنترل (12نفر) تقسیم شدند.. گروه تمرین ترکیبی به مدت 3 ماه هفته ای3جلسه تمرینات هوازی و مقاومتی را در 60 دقیقه انجام دادند. نمونه هاى خونی 24 ساعت قبل از نخستین جلسه تمرین و 48 ساعت پس از آخرین جلسه تمرین گرفته شد. در بخش آمار استنباطی، از آزمون تی زوجی ، برای مقایسه ی تفاوت های درون گروهی و از آزمون تحلیل کوواریانس برای مقایسه تفاوت های بین گروهی با استفاده از نرم افزار اس پی اس اس نسخه 26 استفاده شد .
نتایج: بر اساس آزمون تی زوجی کاهش معنیداری در میزان سطوح هموسیستئین و پپتید ناتریورتیک مغزی در گروه تمرین ترکیبی پس از تمرینات مشاهده گردید (P<0.05). این کاهش در گروه کنترل معنی دار نبود. تحلیل کوواریانس نشان داد سطوح این دو متغییر در مقایسه با گروه کنترل به طور معنی داری کاهش یافته بود (P<0.05)
نتیجه گیری: به طور کلی نتایج نشان داد اجرای تمرینات ترکیبی هوازی و مقاومتی، می تواند باعث کاهش شاخص التهابی هموسیستئین و همچنین منجر به کاهش پپتید ناتریورتیک مغزی به عنوان بیومارکرقلبی در بیماران قلبی عروقی شود .

کلیدواژه‌ها

عنوان مقاله [English]

The effect of 12 weeks of combined training on serum homocysteine and brain natriuretic peptide (NT-proBNP) in cardiovascular patients

نویسندگان [English]

  • Bita Javaherhaghighi 1
  • Abdolali Benaifar 2
  • Ardeshir Zafari 3
  • Sajjad Arshadi 4
  • Valiollah Shahedi 5
1 PhD student in Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, South Tehran Branch, Iran
2 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, South Tehran Branch, Iran
3 Assistant Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Azad University, Zanjan Branch, Iran
4 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, South Tehran Branch, Iran
5 Assistant Professor, Department of Exercise Physiology, Islamic Azad University, Parand Branch, Iran
چکیده [English]

Background: Inactivity is the basis for many diseases, including cardiovascular diseases. Today, lifestyle changes and consequently cardiovascular diseases are one of the common causes of death in the world. The aim of the present study is to determine the effect of combined exercise (aerobic and resistance) on homocysteine ​​and brain natriuretic peptide (N-terminal proBrain Natriuretic Pepted) levels in cardiovascular patients.
Methods: In this study, which was conducted with a pre-test and post-test design with a control group, 24 volunteer patients were randomly divided into 2 combined exercise groups (12 people) and control (12 people). The combined exercise group performed 3 sessions of aerobic and resistance exercises for 60 minutes per week for 3 months. Blood samples were taken 24 hours before the first exercise session and 48 hours after the last exercise session. In the inferential statistics section, paired t-test was used to compare intra-group differences and analysis of covariance was used to compare inter-group differences using SPSS version 26 software.
Results: Based on paired t-test, a significant decrease in homocysteine ​​and brain natriuretic peptide levels was observed in the combined exercise group after exercise (P<0.05). This decrease was not significant in the control group. Covariance analysis showed that the levels of these two variables were significantly reduced compared to the control group (P<0.05). Conclusion: In general, the results showed that performing combined aerobic and resistance exercises can reduce the homocysteine ​​inflammatory index and also lead to a decrease in brain natriuretic peptide as a cardiac biomarker in cardiovascular patients.

کلیدواژه‌ها [English]

  • Combined exercise
  • cardiovascular disease
  • homocysteine
  • and brain natriuretic peptide

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مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 68، شماره 2
خرداد-تیر1404
خرداد و تیر 1404

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