The effect of a period of endurance training combined with sumac supplementation on serum levels of mitochondrial sirtuins (SIRT3, SIRT4) and AMPK in male Wistar rats with Alzheimer's disease
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Associate Professor Neuroscience Research Center, Kerman University of Medical Sciences
10.22038/mjms.2025.81265.4678
Abstract
Introduction: The aim of this study was to investigate the effect of 12 weeks of endurance training with sumac intake on the serum levels of SIR3, SIR4 and AMPK in Alzheimer's male rats. Methods: In this experimental study, 35 Wistar rats aged 8-10 weeks and average weight of 230±30 grams were randomly divided into five groups: control, Alzheimer's disease, Alzheimer's disease with sumac supplementation, Alzheimer's disease with endurance training, and Alzheimer's disease with They were divided by endurance training and receiving sumac supplements. To induce Alzheimer's disease, 8 mg/kg of trimethyl tin chloride along with 200 microliters of normal saline were injected into mice. Endurance training was done for 12 weeks and 5 days a week and blood samples were taken. Serum levels of SIR3, SIR4 and AMPK were evaluated by ELISA method. The data were analyzed by one-way ANOVA method along with Tukey's post hoc test at a significance level of P<0.05. Results: The results of this research showed that 12 weeks of endurance training increased the levels of SIR3 (P<0.002), SIR4 (P<0.001) and AMPK (P<0.031) compared to the Alzheimer group. In addition, adding sumac to the endurance training program had a significant effect on SIR3 (P<0.001), SIR4 (P<0.001) and AMPK (P<0.0001). Conclusion: Our results suggest that endurance training is associated with improving the levels of sirtuin 3, sirtuin 4 and adenosine monophosphate kinase in Alzheimer's rats, and receiving sumac antioxidant compound leads to doubling of these responses.
amini, R. , saremi, A. and Afarinesh, M. (2025). The effect of a period of endurance training combined with sumac supplementation on serum levels of mitochondrial sirtuins (SIRT3, SIRT4) and AMPK in male Wistar rats with Alzheimer's disease. Medical Journal of Mashhad university of Medical Sciences, (), -. doi: 10.22038/mjms.2025.81265.4678
MLA
amini, R. , , saremi, A. , and Afarinesh, M. . "The effect of a period of endurance training combined with sumac supplementation on serum levels of mitochondrial sirtuins (SIRT3, SIRT4) and AMPK in male Wistar rats with Alzheimer's disease", Medical Journal of Mashhad university of Medical Sciences, , , 2025, -. doi: 10.22038/mjms.2025.81265.4678
HARVARD
amini, R., saremi, A., Afarinesh, M. (2025). 'The effect of a period of endurance training combined with sumac supplementation on serum levels of mitochondrial sirtuins (SIRT3, SIRT4) and AMPK in male Wistar rats with Alzheimer's disease', Medical Journal of Mashhad university of Medical Sciences, (), pp. -. doi: 10.22038/mjms.2025.81265.4678
CHICAGO
R. amini , A. saremi and M. Afarinesh, "The effect of a period of endurance training combined with sumac supplementation on serum levels of mitochondrial sirtuins (SIRT3, SIRT4) and AMPK in male Wistar rats with Alzheimer's disease," Medical Journal of Mashhad university of Medical Sciences, (2025): -, doi: 10.22038/mjms.2025.81265.4678
VANCOUVER
amini, R., saremi, A., Afarinesh, M. The effect of a period of endurance training combined with sumac supplementation on serum levels of mitochondrial sirtuins (SIRT3, SIRT4) and AMPK in male Wistar rats with Alzheimer's disease. Medical Journal of Mashhad university of Medical Sciences, 2025; (): -. doi: 10.22038/mjms.2025.81265.4678
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