ارزیابی تغییرات سطوح سرمی مولکول‌های چسبان سلولی و عروقی به تمرینات مقاومتی در بزرگسالان: یک مرور نظام ‏مند و فراتحلیل

نوع مقاله : مقاله مروری

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه یاسوج، یاسوج، ایران.

2 گروه فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه اراک، اراک، ایران.

3 گروه علوم ورزشی، دانشکده علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران.‌

10.22038/mjms.2025.89716.5072

چکیده

مقدمه: این مطالعه مروری فراتحلیل، با هدف ارزیابی تاثیر تمرینات مقاومتی بر سطوح پلاسمایی مولکول‌‌های چسبان بین سلولی 1 (ICAM-1) و عروقی 1 (VCAM-1) در بزرگسالان انجام پذیرفت.
روش کار: جهت شناسایی مطالعات انجام شده کلمات کلیدی مرتبط در پایگاه‌های اطلاعاتیPubMed ،Web of Science ، Scopus، ‌Magiran‌، Irandon،Noor Mags و SID از سال 1385 تا 10 خردادماه 1404 (2006 تا 31 می 2025)، جستجو گردید و کلیه مطالعاتی که در این زمینه به چاپ رسیده بودند، استخراج شد. پس از غربالگری مقالات، 12 مطالعه که معیارهای ورود به مطالعه را دارا بودند، وارد فراتحلیل شدند. تفاوت میانگین وزنی (SMD) و فاصله اطمینان 95 درصد (CI) با استفاده از الگوی تصادفی و از نرم‌افزار CMA2 به منظور تعیین اثر محاسبه گردید.
نتایج: در مجموع 12 مطالعه (با 14 مداخله تمرین مقاومتی) روی 298 آزمودنی بزرگسال فراتحلیل شدند و نتایج نشان داد مداخله تمرین مقاومتی در افراد بزرگسال با کاهش معنادار ICAM-1 ]001/0 P= ،(557/2- الی 857/0-) 707/1- =‌ [SMDنسبت به گروه شاهد می‌شود. اما تغییر غیرمعنادار در VCAM-1 ]518/0 P= ،(752/1- الی 884/0) 905/0- =‌ [SMDملاحضه گردید.
نتیجه گیری: فراتحلیل حاضر نشان داد که تمرین مقاومتی در بزرگسالان منجر به کاهش معنادار ICAM-1 می‌شود، در حالی که تغییرات VCAM-1 غیرمعنادار بود. این یافته‌ها نشان می‌دهد که تمرین مقاومتی می‌تواند اثرات مفیدی بر شاخص‌های التهابی مرتبط با سلامت قلب و عروق داشته باشد، هرچند تأثیر آن بر VCAM-1 نیازمند بررسی‌های بیشتر است.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Evaluation of changes in serum levels of cell and vascular adhesion molecules upon resistance training in adults: a systematic review and meta-analysis

نویسندگان [English]

  • Omid Zafarmand 1
  • Abbas Saremi 2
  • Mehdi Mogharnasi 3
1 Department of Physical Education and Sports Sciences, School of Humanities, University of Yasouj, Yasouj, Iran.
2 Department of Exercise Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran.
3 Department of Sports Sciences, University of Birjand, Birjand, Iran.
چکیده [English]

Introduction: This systematic review and meta-analysis aimed to evaluate the effects of resistance training on plasma levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in adults.
Materials and Methods: To identify relevant studies, related keywords were searched in the PubMed, Web of Science, Scopus, Magiran, Irandon, Noor Mags, and SID databases from 2006 to May 31, 2025. All studies published on this topic were retrieved. After screening the articles, 12 studies that met the inclusion criteria were included in the meta-analysis. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using a random-effects model in CMA2 software to determine the effect.
Results: A total of 12 studies (with 14 resistance training interventions) involving 298 adult participants were included in the meta-analysis. The results showed that resistance training in adults was associated with a significant reduction in ICAM-1 compared with the control group [SMD = -1.707, 95% CI: -2.857 to -0.557, P < 0.001]. However, the change in VCAM-1 was not significant [SMD = -0.905, 95% CI: -1.884 to -0.752, P = 0.518].
Conclusion: The present meta-analysis demonstrated that resistance training in adults led to a significant reduction in ICAM-1, whereas changes in VCAM-1 were not significant. These findings suggest that resistance training may have beneficial effects on inflammation-related markers associated with cardiovascular health, although its impact on VCAM-1 requires further investigation.

کلیدواژه‌ها [English]

  • Resistance Training
  • Adhesion Molecules
  • ICAM-1
  • VCAM-1
  • Adults

مراجع

  1. Mensah GA, Fuster V, Murray CJL, Roth GA. Global Burden of Cardiovascular Diseases and Risks, 1990-2022. J Am Coll Cardiol. 2023;82(25):2350-473.
  2. Jafari M. The Status of Inflammatory Factors Involved in Coronary Artery Disease in Veteran Football Players. Journal of Archives in Military Medicine. 2018;7(3).
  3. Singh V, Kaur R, Kumari P, Pasricha C, Singh R. ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders. Clin Chim Acta. 2023;548:117487.
  4. Haydinger CD, Ashander LM, Tan ACR, Smith JR. Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule. Biology (Basel). 2023;12(5).
  5. Soori R, Zafarmand O. The Effect of Resistance Training on Glycemic Indices and Lipid Profiles in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Iranian Journal of Endocrinology and Metabolism. 2024;25(6):494-508.
  6. Polito MD, Dias JR, Jr., Papst RR. Resistance training to reduce resting blood pressure and increase muscle strength in users and non-users of anti-hypertensive medication: A meta-analysis. Clin Exp Hypertens. 2021;43(5):474-85.
  7. Khalafi M, Malandish A, Rosenkranz SK, Ravasi AA. Effect of resistance training with and without caloric restriction on visceral fat: A systemic review and meta-analysis. Obes Rev. 2021;22(9):e13275.
  8. Soori R, Rezaeian N, Khosravi N, Ahmadizad S, Taleghani HM, Jourkesh M, Stannard SR. Effects of water-based endurance training, resistance training, and combined water and resistance training programs on visfatin and ICAM-1 levels in sedentary obese women. Science & Sports. 2017;32(3):144-51.
  9. Hooshmand Moghadam B, Moazamigoudarzi S, Rashidlamir A, Hooshmand-Moghadam B. Evaluation of serum levels of cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) following a resistance training program in middle-aged and elderly men with hypertension. KAUMS. 2024;28(6):622.
  10. Timon R, Martínez-Guardado I, Camacho-Cardeñosa A, Villa-Andrada JM, Olcina G, Camacho-Cardeñosa M. Effect of intermittent hypoxic conditioning on inflammatory biomarkers in older adults. Exp Gerontol. 2021;152:111478.
  11. Olson TP, Dengel DR, Leon AS, Schmitz KH. Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women. Int J Obes (Lond). 2007;31(6):996-1003.
  12. Boeno FP, Ramis TR, Munhoz SV, Farinha JB, Moritz CEJ, Leal-Menezes R, et al. Effect of aerobic and resistance exercise training on inflammation, endothelial function and ambulatory blood pressure in middle-aged hypertensive patients. J Hypertens. 2020;38(12):2501-9.
  13. Sattarzadeh L, Peeri M, Azarbaijani M, Matin Homaee H. To Determine the Effect of Two Methods of Upper and Lower Resistance Training on Inflammatory Markers Levels of C-Reactive protein, Interleukin-6 and Intracellular Adhesion Molecule-1 in Healthy Untrained Women. Sport Physiology & Management Investigations. 2018;9(4):17-27.
  14. Khalafi M, Symonds ME, Sakhaei MH, Ghasemi F. The effects of exercise training on circulating adhesion molecules in adults: A systematic review and meta-analysis. PLoS One. 2023;18(10):e0292734.
  15. Malandish A, Karimi A, Naderi M, Ghadamyari N, Gulati M. Impacts of Exercise Interventions on Inflammatory Markers and Vascular Adhesion Molecules in Patients With Heart Failure: A Meta-analysis of RCTs. CJC Open. 2023;5(6):429-53.
  16. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1.
  17. Tarsilla M. Cochrane Handbook for Systematic Reviews of Interventions. Journal of Multidisciplinary Evaluation. 2008;6:142-8.
  18. Mogharnasi M, Kazeminasab F, Zafarmand O, Hassanpour N. The effect of aerobic and resistance training on Omentin-1 and Nesfatin-1 levels in adults: A systematic review and meta -Analysis. Journal of Birjand University of Medical Sciences. 2024;30(4):295-315.
  19. Kazemi Nesab F, Zafarmand O. Comparison of the effects of high-intensity intermittent training and moderate-intensity continuous training on cardiometabolic factors in type 2 diabetic patients: a systematic review and meta-analysis. Feyz Medical Sciences Journal. 2024;28(1):96-109.
  20. Zafarmand O, Mogharnasi M, Moghadasi M. The effect of exercise training on serum levels of adipokines related to energy homeostasis (adropin, asprosin) and insulin resistance in patients with type 2 diabetes or obesity: A Systematic review and meta-Analysis. Journal of Applied Health Studies in Sport Physiology. 2024:-.
  21. Kazeminasab F, Sharafifard F, Miraghajani M, Behzadnejad N, Rosenkranz SK. The effects of exercise training on insulin resistance in children and adolescents with overweight or obesity: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023;14:1178376.
  22. Khalafi M, Alamdari KA, Symonds ME, Nobari H, Carlos-Vivas J. Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: systematic review and meta-analysis. Hormones (Athens). 2021;20(1):23-33.
  23. Wen H, Wang L. Reducing effect of aerobic exercise on blood pressure of essential hypertensive patients: A meta-analysis. Medicine. 2017;96(11).
  24. Saremi A, Zafarmand O. The Effect of High-Intensity Interval Training on Plasma Irisin Levels and Glycemic Indices in Obese and Type 2 Diabetic People: A Systematic Review and Meta-Analysis. Iranian Journal of Diabetes and Lipid Disorders. 2025;25(2):85-100.
  25. Mohammadreza Hamedinia AH. The effect of endurance and resistance training on soluble adhesive molecules in the circulation of healthy and moderately obese men. Olympic Quarterly. 2007;15(2):51-7.
  26. Khosravi N SR, Rezaian N. The effect of resistance training on serum sICAM-1 (soluble intercellular adhesion molecule-1 levels in sedentary obese postmenopausal women. Applied Exercise Physiology Research Paper. 2011;7(14):29-44.
  27. Soori R, Khosravi n, Rezaeian N, Montazeri H. Effects of Resistance and Endurance Training on Coronary Heart Disease Biomarker in Sedentary Obese Women. IJEM. 2011;13(2):179.
  28. Nikseresht M, Sadeghifard N, Agha-Alinejad H, Ebrahim K. Inflammatory markers and adipocytokine responses to exercise training and detraining in men who are obese. J Strength Cond Res. 2014;28(12):3399-410.
  29. Nayenifar S, Afzalpour ME, Saqib Joo M, Hedayati M. The effect of resistance and aerobic exercises on soluble intercellular adhesive molecule and serum lipid profile of overweight women. Journal of Sports and Biomotor Sciences. 2011;2(4):77-87.
  30. Rosety I, Pery MT, Rosety J, García N, Rodríguez-Pareja MA, Brenes-Martín F, et al. [Circuit resistance training improved endothelial dysfunction in obese aged women]. Nutr Hosp. 2016;33(1):17.
  31. Chaudhari A, Padmar J, Awathale S, Goyal S, Nakhate K, Sheriker A. From glial cells to pain pathways: ICAM-1 as a central player in neuroinflammation and neuropathy. Discover Neuroscience. 2025;20.
  32. Bui TM, Wiesolek HL, Sumagin R. ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis. J Leukoc Biol. 2020;108(3):787-99.
  33. Zhou X, Xu T, Li C, He Y, Hu Y, Gong H, et al. Potentiating anti-tumor immunity by re-engaging immune synapse molecules. Cell Rep Med. 2025;6(3):101975.
  34. Kaur G, Sharma D, Bisen S, Mukhopadhyay CS, Gurdziel K, Singh NK. Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization. Commun Biol. 2023;6(1):516.
  35. Silva VR, Azar A, Goncalves ER, Nascimento TCM, Buchaim RL, Buchaim DV, et al. MicroRNA-Mediated Regulation of Vascular Endothelium: From Pro-Inflammation to Atherosclerosis. Int J Mol Sci. 2025;26(13).
  36. Minjares M, Wu W, Wang JM. Oxidative Stress and MicroRNAs in Endothelial Cells under Metabolic Disorders. Cells. 2023;12(9).
مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 69، شماره 3
خرداد1405
خرداد 1405
صفحه 282-299

فایل ها

هم رسانی

ارجاع به این مقاله

آمار