بررسی تأثیر نبولایزر بودزوناید بر روند بهبودی و درمان کودکان مبتلابه پنومونی 1ماه تا 5 سال: یک کار آزمایی بالینی تصادفی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دستیار کودکان، گروه کودکان، دانشکده پزشکی، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران.

2 استادیارتخصصی آمار زیستی، مرکز تحقیقات مدل سازی در سلامت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران.

3 استادیار فوق تخصص آسم و آلرژی گروه کودکان ، دانشگاه علوم پزشکی شهرکرد، شهرکرد ، ایران

4 استادیار فوق تخصص آسم و آلرژی گروه کودکان، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران

10.22038/mjms.2025.90457.5089

چکیده

زمینه: مطالعه حاضر باهدف بررسی تأثیر نبولایزر بودزوناید بر روند بهبودی و درمان کودکان مبتلا به پنومونی ۱ ماه تا ۵ سال انجام گردید.
روش بررسی: پژوهش حاضر یک کار آزمایی بالینی تصادفی شده می‌باشد که در سال 1403 در بیمارستان هاجر شهرکرد روی 122 کودک 1 ماه تا 5 سال مبتلا به پنومونی اکتسابی از جامعه انجام شد. معاینات اولیه ،سطح WBC، ESR و CRP سرمی و نمره PRESS قبل از مداخله اندازه‌گیری شد. کودکان به 2 گروه 61 نفره مداخله و کنترل تقسیم شدند. به گروه مداخله علاوه بر درمان‌های معمول 5 روز نبولایزر بودزوناید 5/0میلی‌گرم هر 12 ساعت داده شد. در طول مطالعه درجه حرارت بدن، ضربان قلب و تنفس در دقیقه، درصد اشباع اکسیژن ، رال ریه و تعداد روزهای بستری ثبت گردید. مداخله فاکتورهای سرمی مجدداً اندازه گیری شد.
یافته‌ها: نتایج مطالعه حاضر نشان داد بین تعداد روزهای بستری، روند تغییرات درجه حرارت بدن، تعداد تنفس و ضربان قلب، سطح اکسیژن خون و همچنین زمان توقف سرفه، رال ریه، استفراغ، استفاده از عضلات فرعی و نیاز به مایعات داخل وریدی بین گروه کنترل و مداخله تفاوت معنادار وجود ندارد. تفاوت میانگین سطح WBC، ESR، CRP قبل و بعد از مداخله بین گروه کنترل و مداخله تفاوت معنادار ندارد (˂p05/0).
نتیجه: نبولایزر بودزوناید در تعداد روزهای بستری، روند درجه حرارت بدن، تعداد ضربان قلب، تعداد تنفس، سطح اکسیژن خون، تعداد حملات سرفه، وضعیت رال ریه ، استفراغ ، استفاده از عضلات فرعی و نیاز به مایعات داخل وریدی در طول مطالعه تأثیر معناداری نداشته است.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Investigating the effect of budesonide nebulizer on healing and treatment process of children with pneumonia aged 1 month to 5 years: a randomized clinical trial

نویسندگان [English]

  • Mahsa Banitalebi 1
  • Moluk Hadi Alijanvand 2
  • Javad Fadaee Tehrani 3
  • Mohammad Ali Zamani 4
1 Pediatric Resident, Department of pediatrics, school of medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Assistant professor of Allergy and clinical Immunology, Department of pediatrics, school of medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Assistant professor of Allergy and clinical Immunology, Department of pediatrics, school of medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
چکیده [English]

Background: Pneumonia is the first cause of death in children worldwide. Using anti-inflammatory drugs such as corticosteroid with antimicrobial treatment can be a suitable treatment.
Objectives: This study was conducted to investigate the effect of budesonide nebulizer on the healing process and treatment of children with pneumonia aged 1 month to 5 years.
Methods: This study is a randomized clinical trial, conducted in 2024 in Hajar Shahrekord Hospital on 122 children With Community Acquired Pneumonia aged 1 month to 5 years. After Initial examinations, serum WBC, ESR and CRP levels and PRESS score were measured before the intervention. Children were randomly divided into intervention (n=61) and control (n=61) groups. In addition to the usual treatments, the intervention group was given 0.5 mg budesonide nebulizer every 12 hours for 5 days. During the study, body temperature, heart rate and respiratory rate, blood oxygen saturation, pulmonary Rale, cough frequency and days of hospitalization were recorded. At the end of the intervention, serum factors were measured again.
Results: The results showed there was no significant difference in hospitalization days, body temperature, respiratory rate and heart rate, blood oxygen saturation, cough frequency, pulmonary rales and accessory muscles use (0.05˂p). WBC, ESR and CRP changes before and after intervention between the 2 groups hadn’t significant differences (p=0.77)
Conclusions: Budesonide nebulizer didn’t have a significant effect on hospitalization days, heart rate, respiratory rate, O2 saturation, cough frequency, accessory muscles use, pulmonary rales and fever disappearance and inflammatory markers during the study.

کلیدواژه‌ها [English]

  • Pneumonia
  • Nebulizer
  • Budesonide
  • Pulmicort
  • Pediatric

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مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 69، شماره 2
اردیبهشت1405
اردیبهشت 1405
صفحه 130-141

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