نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجوی دکترای تخصصی فیزیولوژی ورزشی، واحد تهران جنوب، دانشگاه آزاد اسلامی، تهران، ایران.
2 دانشیار گروه فیزیولوژی ورزشی، واحد تهران جنوب، دانشگاه آزاد اسلامی، تهران، ایران.
3 استادیار گروه فیزیولوژی ورزشی، واحد ساوه، دانشگاه آزاد اسلامی، اراک، ایران.
4 استادیار آسیب شناسی ورزشی، واحد تهران جنوب، دانشگاه آزاد اسلامی، تهران، ایران.
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Introduction: Breast cancer is the most common cancer and the leading cause of cancer-related death among women. In 2018, about ½ million people were diagnosed with breast cancer worldwide, and about one in four women had breast cancer. Exercise training can have different effects on cancer control by affecting microRNAs.
Methods: The statistical population of the present study consisted of all female Balb C mice of the Laboratory Animal Center of Shiraz University of Medical Sciences, which were purchased from a statistical population of 90 10-week-old female Balb C mice weighing 17±2 grams. An aerobic, interval, and resistance training program was performed for 12 weeks, 5 sessions per week, with a gradual increase in intensity and duration. Shapiro-Wilk, Levine, one-way analysis of variance, and Tukey post hoc tests were used to analyze the data. Daily consumption of 0.1 ml of alfalfa extract was done via intraperitoneal injection for 12 weeks.
Results: The results showed that the level of mir126 was increased in all training groups with and without alfalfa extract consumption, but this level was more significant in the endurance training groups with and without alfalfa extract consumption than in the other groups.
Conclusion: The present study showed that exercise training combined with alfalfa consumption can play a very important role in modulating and controlling breast cancer conditions by increasing microRNAs.
کلیدواژهها [English]
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