بی اشتهایی عصبی تظاهری از یک بیماری جدی در نوجوانان: گزارش یک مورد بالینی

نوع مقاله : گزارش مورد

نویسندگان

1 گروه تغذیه، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد ، مشهد، ایران

2 گروه تغذیه، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد ، مشهد ، ایران

3 گروه گوارش کودکان، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

10.22038/mjms.2025.88159.5013

چکیده

چکیده
ایدز در نوجوانان یک چالش جدی بهداشتی است که نیازمند آگاهی، تشخیص زودهنگام و درمان مناسب است. با شناخت علائم و انجام آزمایش‌های لازم، می‌توان از پیشرفت بیماری جلوگیری کرد و کیفیت زندگی نوجوانان مبتلا را بهبود بخشید. در این گزارش موردی به بررسی یک مرود ایدز در نوجوان پرداخته شده است. بیمار پسر 17 ساله بدون سابقه بیماری زمینه ای قبلی، به دنبال اعتصاب غذا با کاهش وزن شدید، آنورکسیا نروزا، اسهال خونی و استفراغ به بیمارستان مراجعه کرد. بیمار تحت تغذیه درمانی پزشکی و اندو-کولونوسکوپی قرار گرفت و با توجه به کولیت فعال روده ابتدا با شک به IBD ودرنهایت با تشخیص HIV به بخش مربوطه منتقل شد. اقدامات تیمی درمان منجر به بهبودی نسبی علائم از جمله کاهش اشتها، اسهال، درد عضلانی شد. تغذیه بهینه می‌تواند به حفظ توده بدون چربی بدن، کاهش شدت علائم مرتبط با HIV، افزایش پشتیبانی از درمان ضد رتروویروسی و بهبود کیفیت زندگی کمک کند. دستورالعمل‌های ESPEN بیان می‌کند که نیازهای انرژی باید در طول مرحله بهبودی پس از عفونت‌های فرصت‌طلب 20 تا 30 درصد افزایش یابد. این دستورالعمل‌ها مصرف پروتئین 1.2-1.5 گرم بر کیلوگرم را به ترتیب در فاز فعال و فاز غیر فعال این بیماری توصیه می‌کند.همچنین مواد ریزمغذی از جمله ویتامین ها C و D نقش مهمی در بهبود سلامت سیستم ایمنی در این بیماران دارد و در کنترل علائم بیماری ایدز از جمله التهاب و کاهش علائم گوارشی از جمله اسهال میتواند اثر بخش باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Anorexia Nervosa as a Manifestation of a Serious Illness in Adolescents: A Clinical Case Report

نویسندگان [English]

  • Samira Mawdoodi 1
  • parastoo Asghari 2
  • Hamid Reza Kianifar 3
  • saeedeh talebi 2
1 Department of Nutrition, faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Nutrition, faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Pediatrics, faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Abstract

AIDS in adolescents presents a significant health challenge that necessitates awareness, early diagnosis, and appropriate treatment. By recognizing the symptoms and conducting the necessary tests, the progression of the disease can be halted, and the quality of life for affected adolescents can be enhanced. This case report examines an instance of AIDS in an adolescent. A 17-year-old male patient, with no prior history of underlying health issues, was admitted to the hospital following a hunger strike, which resulted in severe weight loss, anorexia nervosa, bloody diarrhea, and vomiting. The patient received medical nutrition therapy and underwent endo-colonoscopy, subsequently being transferred to the relevant department due to active colitis. Initially suspected to have inflammatory bowel disease (IBD), he was ultimately diagnosed with HIV. Team-based treatment measures resulted in partial improvement of symptoms, including reduced appetite, diarrhea, and muscle pain. Optimal nutrition is crucial for maintaining lean body mass, alleviating the severity of HIV-related symptoms, supporting antiretroviral therapy, and enhancing overall quality of life. According to ESPEN guidelines, energy requirements should increase by 20 to 30% during the recovery phase following opportunistic infections. These guidelines also recommend a protein intake of 1.2-1.5 g/kg during both the active and inactive phases of the disease. Additionally, micronutrients, such as vitamins C and D, play a vital role in bolstering immune system health in these patients and can effectively help manage AIDS symptoms, including inflammation and gastrointestinal issues like diarrhea.

کلیدواژه‌ها [English]

  • AIDS disease
  • anorexia nervosa
  • adolescent
  • nutrition therapy
  1. Deeks SG, Tracy R, Douek DC. Systemic effects of inflammation on health during chronic HIV infection. Immunity. 2013;39(4):633-45.
  2. https://data.unicef.org/topic/hivaids/adolescents-young-people/2024.
  3. Kapila A, Chaudhary S, Sharma R, Vashist H, Sisodia S, Gupta A. A review on: Hiv aids. Indian Journal of Pharmaceutical and Biological Research. 2016;4(3):69-73.
  4. Kêdoté NM, Duguet AM, Agbahoungba JG, Gangbo FA. [Not Available]. Journal international de bioethique et d'ethique des sciences. 2024;34(3):47-68.
  5. Christian P, Smith ER. Adolescent undernutrition: global burden, physiology, and nutritional risks. Annals of nutrition and metabolism. 2018;72(4):316-28.
  6. Moro JC, Moreira NM. Clinico-epidemiological and sociodemographic profile of HIV/AIDS patients who are co-infected with Toxoplasma gondii in the border region of Brazil. Anais da Academia Brasileira de Ciencias. 2020;92(4):e20200293.
  7. Hussen S, Belachew T, Hussien N. Nutritional status and its effect on treatment outcome among HIV infected clients receiving HAART in Ethiopia: a cohort study. AIDS research and therapy. 2016;13:32.
  8. Proikaki S, Georgiadis N, Sergentanis TN, Kornarou E, Vassilakou T. Nutritional Status of Adult People Living with HIV: A Narrative Review. Diseases. 2025;13(2):56.
  9. Alum E, Obeagu E, Ugwu O, Egba S, EjimUti D, Ukaidi C, et al. Confronting Dual Challenges: Substance Abuse and HIV/AIDS. Elite Journal of HIV. 2024;2(5):1-8.
  10. Charron CB, Leung JM. The Safety and Efficacy of Marijuana in Persons Living with HIV. AIDS reviews. 2019;21(2).
  11. Yongnian L, Zhichun W, Yisen H, Yanyan Q, Juhua X, Qiuyan H, et al. Effect of probiotics combined with conventional therapy on AIDS-related diarrhea and its influence on intestinal microecology. Chinese Journal of Microecology. 2024;36(9):1073-8.
  12. Iqbal T, Altaf S, Ahmad A. Overview of Acquired Immunodeficiency Syndrome (AIDS): A Chronic Condition Caused by Human Immunodeficiency Virus (HIV).
  13. Abdu Z, Belayneh W, Dule A, Alemu SS, Wedajo LF, Hajure M, et al. Adult HIV/AIDS patients are more likely to experience anxiety symptoms. Frontiers in Psychiatry. 2025;16:1507020.
  14. Urban B, Cai K, Freestone DM, Hellner M, Bohon C, Arsenault A, et al. Comparison of clinical presentation and treatment response among youth with atypical anorexia nervosa and anorexia nervosa. PloS one. 2025;20(3):e0316572.
  15. Mohajan D, Mohajan HK. Anorexia Nervosa: A Dreadful Psychosocial Health Complication. Journal of Innovations in Medical Research. 2024;3(4):69-75.
  16. Goel A, Pandhare S, Sapkale B. Anorexia nervosa: A narrative review of diagnostic criteria, pathophysiology, and innovative management approaches. Multidisciplinary Reviews. 2025;8(2):2025059-.
  17. Alexandrova Y, Costiniuk CT, Jenabian M-A. Pulmonary immune dysregulation and viral persistence during HIV infection. Frontiers in immunology. 2022;12:808722.
  18. Kim Y, Hyon Y, Jung SS, Lee S, Yoo G, Chung C, et al. Respiratory sound classification for crackles, wheezes, and rhonchi in the clinical field using deep learning. Scientific reports. 2021;11(1):1-11.
  19. De Cock KM, Jaffe HW, Curran JW. Reflections on 40 Years of AIDS. Advances in Clinical Immunology, Medical Microbiology, COVID-19, and Big Data. 2021:231-45.
  20. Frenkel A, Shiloh A, Azulay B, Novack V, Klein M, Dreiher J. The role of lactate dehydrogenase in hospitalized patients, comparing those with pulmonary versus non-pulmonary infections: a nationwide study. PLoS One. 2023;18(3):e0283380.
  21. Verma A, Hine AM, Joelson A, Mei R, Pitts RA, Lebwohl B, et al. The influence of hospitalization and HIV severity on gastrointestinal PCR panel evaluation of HIV-related acute diarrhea in New York City: a retrospective, cross-sectional study. Therapeutic Advances in Gastroenterology. 2022;15:17562848221092593.
  22. Nacher M, Valdes A, Adenis A, Blaizot R, Abboud P, Demar M, et al. Gastrointestinal disseminated histoplasmosis in HIV-infected patients: A descriptive and comparative study. Plos Neglected tropical diseases. 2021;15(1):e0009050.
  23. Mabizela S, Van Wyk B. Viral suppression among adolescents on HIV treatment in the Sedibeng District, Gauteng province. curationis. 2022;45(1):2312.
  24. Gandhi RT, Bedimo R, Hoy JF, Landovitz RJ, Smith DM, Eaton EF, et al. Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2022 recommendations of the International Antiviral Society–USA panel. Jama. 2023;329(1):63-84.
  25. Tang AM, Quick T, Chung M, Wanke CA. Nutrition assessment, counseling, and support interventions to improve health-related outcomes in people living with HIV/AIDS: a systematic review of the literature. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2015;68:S340-S9.
  26. Van Graan AE. Nutritional management in HIV/AIDS infection. World Rev Nutr Diet. 2015;111:130-5.
  27. Ali K, Farrer L, Fassnacht DB, Gulliver A, Bauer S, Griffiths KM. Perceived barriers and facilitators towards help‐seeking for eating disorders: A systematic review. International Journal of Eating Disorders. 2017;50(1):9-21.
  28. Gnanaraj J, Khaliq W, Kotwal S. Pellagra: An Unusual Cause for Altered Mental Status. Cureus. 2024;16(10).
  29. Gibson D, Workman C, Mehler PS. Medical complications of anorexia nervosa and bulimia nervosa. Psychiatric Clinics. 2019;42(2):263-74.
  30. Barrera Escobar S, Villegas Marín MC, López Estrada C, Trompa Romero IM. Approach to Diarrhea in HIV Patients: Narrative Literature Review and Diagnostic Proposal. 2025.
  31. Mulhall B. What Colonic Infections Are Associated With AIDS? Curbside Consultation of the Colon: CRC Press; 2024. p. 83-4.
  32. Ye Y-M, Wei M-H, Lv K-N, Xue X-H, Shen R, Liu J-H. Effects of an anti-inflammatory diet (AID) on maternal and neonatal health outcomes in pregnant Chinese patients with inflammatory bowel disease treated with infliximab (IFX). Scandinavian Journal of Gastroenterology. 2024;59(12):1297-305.
  33. Mor SM, Ndeezi G, Ascolillo LR, Tasimwa HB, Attipa C, Sponseller J, et al. Clinical Significance of Respiratory Involvement in Cryptosporidiosis: Cross-Sectional Study of Children with Diarrhea and Respiratory Symptoms in Uganda. The American Journal of Tropical Medicine and Hygiene. 2024;111(4):796.
  34. Saini AK, Gupta AA, Keservani RK, Kachave RN, Dharmamoorthy G, Kesharwani RK, et al. HIV/AIDS neurological disorders. A Review on Diverse Neurological Disorders: Elsevier; 2024. p. 291-8.
  35. Gefe DB, Thwaini A, Buchholz N. The impact of nutrition and lifestyle on chronic urinary bladder conditions: a literature review. Longhua Chinese Medicine. 2024;7.
  36. Bolayir B, Arik G, Yeşil Y, Kuyumcu ME, Varan HD, Kara Ö, et al. Validation of nutritional risk screening‐2002 in a hospitalized adult population. Nutrition in Clinical Practice. 2019;34(2):297-303.
  37. Khadim R, Al-Fartusie F, editors. Antioxidant vitamins and their effect on immune system. Journal of Physics: Conference Series; 2021: IOP Publishing.
  38. Thevi T, Abas AL, Rajan M. The effects of vitamin C on wound healing—Systematic review. Indian Journal of Surgery. 2024;86(1):23-9.
  39. Kumar J, Sen A. The role of vitamin C: From prevention of pneumonia to treatment of Covid-19. Materials Today: Proceedings. 2022.
  40. Dzavakwa NV, Chisenga M, McHugh G, Filteau S, Gregson CL, Kasonka L, et al. Vitamin D3 and calcium carbonate supplementation for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology (VITALITY trial): study protocol for a randomised placebo-controlled trial. Trials. 2022;23(1):78.
  41. Khodabakhsh M, Jafari A, Banihasan M, Lachin M. اثربخشی رفتار درمانی دیالکتیکی بر ویژگی های خصمانه و رفتارهای پرخطر نوجوانان. مجله اصول بهداشت روانی. 2024;26(3):149-55.
  42. فرد ک, مهین, نصیری, آریاپوران. نقش مشکلات روان‌شناختی، بهزیستی معنوی، سبک‌های فرزندپروری و تنظیم هیجان در تمیز مادران با و بدون نوجوان خانه‌گریز. فرهنگ در دانشگاه اسلامی. 2024;14(51):53-76.