Introduction: Benign prostatic hyperplasia (BPH) is a common disease among middle-aged and elderly men, and with increasing age, the incidence of BPH increases significantly and affects the quality of life of more than 500 million men worldwide. The aim of the present study was to investigate the effect of a six-week resistance training program on the expression levels of p53, P21 and NF-κB genes in the prostate tissue of male rats in the prostate hyperplasia model.
Methods: In this research for this purpose, 21 two-month-old male rats were divided into three groups: control, patient and patient + resistance training and were divided for 6 weeks. Mice in the patient group and patient + resistance training group were injected with testosterone into the benign prostatic hyperplasia and the patient + resistance training group performed a resistance training program for 6 weeks with an intensity of 30 to 100% of the initial weight of the mice. 48 hours after the last training session, the mice were dissected and the expression levels of p53, P21 and NF-κB genes in the prostate tissue of the samples were evaluated using the PCL Real Time method. The results were statistically analyzed using one-way analysis of variance and Tukey's post hoc test at a significance level of P≤0.05.
Results: The result of data analysis showed that prostate hyperplasia led to an increase in the expression of all three genes, P53, P21 and NF-κB proteins (p≤0.0001). However, 6 weeks of resistance training decreased the expression of the aforementioned genes in the prostate tissue of the research samples (p≤0.001).
Conclusion: Overall, the results of the present study showed that 6 weeks of resistance training in mice with benign prostatic hyperplasia led to the control of the P53-P21 inflammatory pathway and inhibition of nuclear factor kappa gene expression. This led to a decrease in chronic inflammation of the prostate tissue and, possibly, in this way, reduced the tendency of immune cells to the prostate tissue and the death of healthy prostate cells.