نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشیار گروه روماتولوژی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
2 - استادیار گروه روماتولوژی، مرکز تحقیقات بیماری‌های روماتیسمی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
3 استادیار گروه مامایی، دانشگاه آزاد اسلامی واحد کرج، کرج، ایران
چکیده
کلیدواژه‌ها
عنوان مقاله [English]
نویسندگان [English]
Introduction
Systemic sclerosis (SSc) is a connective tissue disease with unknown etiology which causes remarkable morbidity and mortality. Raynaud's phenomenon (RP) is a complication of SSc leading to ischemia of extremities and digital gangrenes. Treatment of RP is a clinical problem and often remains inefficient. Ginkgo biloba is derived from the leaf of the Maidenhair tree. Its’ extract is leaded to improve tissue circulation; this study was designed to evaluate the efficacy of ginkgo biloba in the treatment of RP in systemic sclerosis.
Materials and Methods
A total of Seventeen patients with SSc and RP were received either Ginkgo biloba pills (40 mg three times per day) or placebo for 3 months in a randomized, double blind, controlled trial. A two-week assessment period before treatment was done during which patients were asked to record the frequency, duration, and severity [using 10-point Raynaud’s Condition Score (RCS)] of attacks in a diary form before intervention. They continued to record the same data in their diary forms after intervention and were visited at the end of each month.
Results
The mean duration of attacks and the RCS were significantly decreased in Ginkgo group compared with the baseline (P<0.05), whilst no significant reduction was observed in the mean number of attacks (P=0.147). In the placebo group no significant reduction was shown in the mean duration or number of attacks, and RCS.
Conclusion
Ginkgo biloba reduces the duration and severity of Raynaud's attacks of patients with systemic sclerosis.
کلیدواژه‌ها [English]
)