مقایسه تأثیر سه روش مکمل یاری دارچین، تمرین هوازی و ترکیب این دو (تمرین – مکمل) برگلوکز، انسولین ناشتای خون و مقاومت به انسولین مردان دیابتی نوع II

نوع مقاله : مقاله پژوهشی

نویسندگان

1 استادیار فیزیولوژی ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد خمینی‌شهر، خمینی‌شهر، اصفهان، ایران

2 کارشناسی ارشد فیزیولوژی ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد خمینی‌شهر، خمینی‌شهر، اصفهان، ایران

چکیده

مقدمه
تا کنون روش‌های درمانی متعددی برای درمان بیماری دیابت پیشنهاد شده‌است، اما این که کدام یک از این روش‌ها با توجه به شرایط بیمار، کارایی بیشتری دارد، هنوز به روشنی مشخص نشده است. لذا، هدف از پژوهش حاضر مقایسه تأثیر سه روش مصرف دارچین، تمرینات هوازی و ترکیب آنها بر گلوکز و انسولین ناشتای خون و مقاومت به انسولین مردان دیابتی نوع II بود.
روش کار
در این پژوهش که به‌صورت پیش آزمون – پس آزمون با گروه کنترل انجام شد، 56 مرد دیابتی به‌طور تصادفی به 4 گروه مصرف دارچین (14 نفر)، تمرین هوازی (14 نفر)، ترکیبی (14 نفر) و کنترل (14 نفر) تقسیم شدند. گروه دارچین روزانه 6 کپسول 500 میلی‌گرمی دارچین به مدت 8 هفته مصرف کردند، گروه تمرین هوازی هفته‌ای 3 جلسه به مدت35 تا 45 دقیقه و با شدت60  تا 70% ضربان قلب بیشینه در 8 هفته تمرین کردند، و گروه ترکیبی به‌طور همزمان به تمرین هوازی و مصرف دارچین پرداختند. متغیرها در ابتدا و پس از 8 هفته مداخله اندازه‌گیری شد. مقایسه درون‌گروهی با آزمون t همبسته و مقایسه بین‌گروهی با تحلیل واریانس یک‌طرفه (ANOVA) انجام شد.
نتایج
در هر سه گروه مداخله؛ گلوکز، انسولین ناشتای خون و مقاومت به انسولین در مقایسه با گروه کنترل کاهش معناداری داشت (05/0>p). ولی در مقایسه بین گروهی تفاوت معناداری در کاهش گلوکز ناشتای خون و مقاومت به انسولین مشاهده نشد.
نتیجه ­گیری
مصرف دارچین، تمرین هوازی و روش ترکیبی می‌تواند روی کاهش گلوکز، سطح انسولین و مقاومت انسولینی اثرات مثبتی داشته باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Comparing the Effects of Three Methods, Cinnamon Supplementation, Aerobic Exercise and Concurrent (Aerobic Exercise - Supplement) on Serum Glucose, Insulin and Insulin Resistance in Type 2 Diabetic Patients

نویسندگان [English]

  • Allahyar Arabmomeni 1
  • Mehdi Haji Hidari 2
1 Assistante professor, Department of Human Science, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr/Isfahan, Iran
2 M.s, Department of Human Science, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr /Isfahan, Iran
چکیده [English]

Abstract
Introduction: Several treatments have been proposed for treating diabetes; however it is still unclear which one of these methods is more effective with regard to patient conditions. Therefore, the purpose of this study was to investigate the effect of 8 weeks of aerobic exercise and concurrent (aerobic resistance) exercise on serum glucose, insulin and insulin resistance levels in Type 2 diabetic patients.
Materials and Methods: In this quasi-experimental study, which was performed as a pre-test, post-test with a control group, 56 type 2 diabetic men randomly assigned into Cinnamon  supplement (14 person) , aerobic exercise (14 person), supplement + exercise (14 person) and  control groups (14 person). The Cinnamon  supplement group received 6 capsule containing 500 mg powder of cinnamon for 8 weeks.  Training program for the aerobic group included 3 sessions with 35 – 45 minutes of running per week with 60 to70% maximal heart rate for 8 weeks and the concurrent group performed aerobic exercise and received cinnamon simultaneously. The variables were measured at baseline and after 8 weeks of intervention. Data were analyzed by t-test and ANOVA at significance level of pResults: Fasting blood glucose, insulin and HOMA-IR were significantly decreases in three groups compared to control group (p<0.05), but no significant decreased were observed for these indexes between groups.
Conclusion: Cinnamon supplementation, aerobic exercise and concurrent methods, can have positive effects on fasting blood glucose, insulin and insulin resistance.

کلیدواژه‌ها [English]

  • Cinnamon
  • Aerobic Exercise
  • Type 2 Diabetic
  • Insulin Resistance

مراجع

  1. References

    1. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15:539-53.
    2. Gomez-Perez FJ, Aguilar-Salinas CA, Almeda-Valdes P, Cuevas-Ramos D, Lerman Garber I, Garber IL, et al. HbA1c for the diagnosis of diabetes mellitus in a developing country. Arch Med Res 2010; 41:302-8.
    3. Larejani B, Zahedi F. Epidemiology of diabetes mellitus in Iran. Iran J Diabetes Metab 2001; 1:1-8. (Persian)
    4. Steinmetz A. Treatment of diabetic dyslipoproteinemia. Exp Clin Endol Diabetes 2003; 111:239-45.
    5. King GL. Mechanism of diabetic microvascular complications. Philadelphia: Joslin's Diabetes Mellitus; 1994. P. 631-47.
    6. Shapiro K, Gong WC. Natural products used for diabetes. J Am Pharm Assoc 2002; 42:217-26.
    7. Ebadi M. Pharmacodynamic basis of herbal medicine. Boca Raton 2002; 14:135-43.
    8. Anderson RA. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc 2008; 67:48-53.
    9. Cao H, Polansky MM, Anderson RA. Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse3T3-L1 apidocytes. Arch Biochem Biophys 2007; 459:214-22.
    10. Imparl-Radosevich J, Deas S, Polansky MM, Baedke DA, Ingebritsen TS, Anderson RA, et al. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signaling. Horm Res 1998; 50:177-82.
    11. Khan A, Safdar M, Alikhan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003; 26:3215-8.
    12. Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE. Effect of cinnamon on glucose and lipid levels in non-insulin-dependent type 2 diabetes. Diabetes Care 2007; 30:2236-7. 
    13. Hosseini SE, Shojaei ST, Hosseini SA. The effects of cinnamon on glycemic indexes and insulin resistance in adult male diabetic rats with streptozotocin. Yafte 2015; 16:70-8. (Persian)
    14. Hasanzade F, Tolyat M, Emami A, Barakchi A, Emamimoghaadam Z. Effect of cinnamon on HbA1c in type 2 diabetes patients. Complementary Med J Facul Nurs Midwifery 2013; 2:303-11.
    15. Haghighian HK, Farsad Naimi A, Pourghasem Gargari B, Ali-Asgharzadeh A, Nemati A. Effect of cinnamon on glycemic control and insulin resistance in type II diabetes patients: a randomized clinical trial. J Ardabil Univ Med Sci 2010; 10:265-302. (Persian)
    16. Mirfeizi M, Mehdizadeh Tourzani Z, Mirfeizi SZ, Asghari Jafarabadi M, Rezvani H, Shoghi M. Effects of cinnamon on controlling blood glucose and lipids in patients with type II diabetes mellitus: A double blind, randomized clinical trial. Med J Mashhad Univ Med Sci 2014; 57:533-41.
    17. Balagopal P, George D, Sweeten S, Mann KJ, Yarandi H, Mauras N, et al. Response of fractional synthesisrate (FSR) of fibrinogen, concentration of D dimer and fibrinolytic balance to physical activity based interventionin obese children. J Thromb Haemostasis 2008; 6:1296-303.
    18. Chen L, Pei JH, Kuang J, Chen HM, Chen Z, Li ZW, et al. Effect of lifestyle intervention in patients with type 2 diabetes: a meta-analysis. Metabolism 2015; 64:338-47.
    19. Abedi B, Okhovat E, Banitalebi E. Comparing the effects of intense sprint and combined aerobic-strength training on serum adiponectin level and insulin resistance among the women with type 2 diabetes. Feyz J 2016; 20:352-60. (Persian)
    20. Tashakorizade M, Mogharansi M. A study of the effect of 10 weeks of resistance training on HSP70 and insulin resistance in type 2 diabetic women. J Sport Biosci 2016; 8:341-51.
    21. Baharloo S, Taghiyan F, Hedayati M. Effect of aerobic exercise on glucose, insulin and insulin resistance in subclinical hypothyroidism overweight-obese women. Razi J Med Sci 2014; 21:75-84. (Persian)
    22. McCormack SE, McCarthy MA, Harrington SG, Farilla L, Hrovat MI, Systrom DM, et al. Effects of exercise and lifestyle modification on fitness, insulin resistance, skeletal muscle oxidative phosphorylation and intramyocellular lipid content in obese children and adolescents. Pediatr Obes 2014; 9:281-91.
    23. O'Leary VB, Jorett AE, Marchetti CM, Gonzalez F, Phillips SA, Ciaraldi TP, et al. Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults. Am J Physiol Endocrinol Metab 2007; 293:421-7.
    24. Rawal LB, Tapp RJ, Williams ED, Chan C, Yasin S, Oldenburg B. Prevention of type 2 diabetes and its complications in developing countries: a review. Int J Behav Med 2012; 19:121-33.
    25. Bazyar F, Banitalebi E, Amirhosseini SE. The comparison of two methods of exercise (intense interval training and concurrent resistance- endurance training) on fasting sugar, insulin and insulin resistance in women with mellitus diabetes. Armaghane Danesh 2016; 21:123-34. (Persian)
    26. Ramzany N, Gaeini AA, Choobineh S, Kordi MR, Hedayati M. Changes of RBP-4 and insulin resistance after 8 weeks of aerobic training in type 2 diabetic rats. Metab Exerc Bioannual J 2016; 5:89-98. (Persian)
    27. El-Kader SM. Aerobic versus resistance exercise training in modulation of insulin resistance, adipocytokines and inflammatory cytokine levels in obese type 2 diabetic patients. J Adv Res 2011; 2:179-83.
    28. Cuff DJ, Meneilly GS, Martin A, Ignaszewski A, Tildesley HD, Frohlich JJ. Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 2003; 26:2977-82.
    29. Leach MJ, Kumar S. Cinnamon for diabetes mellitus. Cochrane Database Syst Rev 2012; 9:CD007170.
مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 62، شماره 2
خرداد و تیر 1398
صفحه 1430-1439

فایل ها

هم رسانی

ارجاع به این مقاله

آمار