مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد

مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد

تأثیر 6 هفته تمرین هوازی و مصرف ژل خوراکی رویال بر فاکتورهای التهابی بیماران مالتیپل اسکلروزیس

نوع مقاله : مقاله پژوهشی

نویسندگان
رحمت اله مولایی 1
مجید وحیدیان رضازاده 1
علی مقتدری 2
1 گروه علوم ورزشی، دانشگاه سیستان و بلوچستان، زاهدان، ایران
2 دانشکده پزشکی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران
10.22038/mjms.2019.14194
چکیده
مقدمه
پاتوژنز MS شامل التهاب و فاز تخریب اعصاب است. MS با یک التهاب اتوایمیون به غلاف میلین و اغلب با یک حمله ناگهانی آغاز می‌شود؛ سپس وارد مرحله بهبود می‌شود که چند ماه تا چندین سال به طول می‌انجامد. پژوهش حاضر به‌منظور بررسی شش هفته تمرین هوازی و مصرف ژل رویال بر فاکتورهای التهابی TNF-α، hs-CRP و نوتروفیل در بیماران MS انجام شد.
روش کار
در این پژوهش نیمه تجربی، 42 نفر بیمار مبتلابه MS شرکت کردند. آزمودنی‌ها به‌صورت هدفمند انتخاب و به‌صورت تصادفی در 4 گروه:1-«ورزش+ژل رویال» (10 نفر)، 2-«ورزش+دارونما» (10 نفر)،3- «ژل رویال» (11 نفر) و 4-«دارونما» (11 نفر) تقسیم شدند. تمرین به مدت 6 هفته، هر هفته 3 جلسه روی چرخ کارسنج و باشدت 60% HRmax انجام شد. سپس به‌صورت پلکانی افزایش یافت و در هفته ششم به 80% HRmax رسید. دوز مصرف روزانه ژل رویال 1000 میلی‌گرم بود. غلظت پلاسمایی فاکتورهای التهابی پیش و پس از پژوهش اندازه‌گیری شد.
نتایج
یافته‌ها نشان داد مقدار TNF-αدر گروه‌های «ورزش+ژل رویال» (039/0=P)،  «ورزش+دارونما» (049/0=P) و «ژل رویال» (015/0=P) کاهش معنی‌داری داشته، اما در گروه «دارونما» معنی‌دار نبود (364/0=P). مقادیر hs-CRP در گروه‌های «ورزش+ژل رویال» (002/0=P)، «ورزش+دارونما» (047/0=P) و «ژل رویال» (042/0=P) تفاوت معنی‌داری داشت. نوتروفیل در گروه‌های «ورزش+ژل رویال» (028/0=P) و «ورزش+دارونما» (010/0=P) کاهش معنی‌داری داشت؛ این میزان در گروه‌های «ژل رویال» (252/0=P) و «دارونما» (365/0=P) معنی‌دار نبود.
نتیجه ­گیری
نتایج این پژوهش نشان داد تمرین هوازی و مصرف ژل رویال باعث بهبود TNF-α، hs-CRP و نوتروفیل در بیماران MS می‌شود.
کلیدواژه‌ها
تمرین هوازی
ژل رویال
فاکتور نکروز دهنده تومور آلفا
پروتئین واکنشگر C
نوتروفیل
مالتیپل اسکلروزیس

عنوان مقاله English

Effect of 6 weeks aerobic exercise and oral Royal Jelly consumption on inflammatory factors' multiple sclerosis patients

نویسندگان English

Rahmatollah Molaei 1
Majid Vahidian-Rezazadeh 1
Ali Moghtaderi 2
1 Department of Sport Sciences, University of Sistan and Baluchestan, Zahedan, Iran
2 Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

کلیدواژه‌ها English

Aerobic Exercise
Royal Jelly
TNF-alpha
C- reactive protein
Neutrophil
Multiple Sclerosis
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مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 62، شماره 3
مرداد-شهریور98- شماره3- دوره62
مرداد و شهریور 1398
صفحه 1524-1535