بررسی سطح سرمی هموسیستئین با درگیری عروق کرونر در بیماران کاندید آنژیوگرافی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی پسادکترا، مرکز بین المللی یونسکو برای علوم پایه مرتبط با بهداشت و تغذیه انسانی ، دانشگاه علوم پزشکی مشهد ، مشهد ، ایران.

2 استادیار پزشکی اجتماعی، واحد توسعه تحقیقات بالینی، بیمارستان قائم، دانشگاه علوم پزشکی مشهد، مشهد، ایران

3 کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد ، مشهد ، ایران

4 استاد، مرکزتحقیقات سندرم متبولیک ، دانشکده پزشکی ، دانشگاه علوم پزشکی مشهد ، مشهد ، ایران. دانشجوی پسادکترا، مرکز بین المللی یونسکو برای علوم پایه مرتبط با بهداشت و تغذیه انسانی ، دانشگاه علوم پزشکی مشهد ، مشهد ، ایران.

5 مرکزتحقیقات قلب، دانشکده پزشکی ، دانشگاه علوم پزشکی مشهد ، مشهد ، ایران

چکیده

مقدمه: بیماریهای قلبی عروقی سالانه سبب مرگ و میر بالایی در ایران و جهان می شوند. ازآنجاییکه ریسک فاکتورهای رایج تنها پیشگویی کننده بخشی از بیماری های قلبی عروقی هستند، پیشنهاد شده است فاکتورهایی مانند اکسیداتیو استرس، برخی فلزات، التهاب و هموسیستئین می توانند عوامل بالقوه ای در ایجاد بیماری های قلبی عروقی داشته باشند. از اینرو در این مطالعه سطح سرمی هموسیستئین با شدت درگیری عروق کرونر مورد بررسی قرار گرفته است.
روش کار: در این مطالعه مقطعی 347 بیمار مراجعه کننده جهت آتژیوگرافی به بیمارستان قائم و 103 فرد سالم بدون علایم قلبی مورد بررسی قرار گرفتند. افراد در 5 گروه با گرفتگی بیش از 50% در یک، دو و سه رگ از عروق قلبی، افراد نرمال کسانی که آنژیوگرافی آنها نرمال بود و یا درگیری کمتر از 50% داشتند و افراد سالم تقسیم شدند. سطح سرمی هموسیستئین با روش ELISA در پژوهشکده بوعلی اندازه گیری گردید. آنالیز داده های آماری با استفاده از نرم افزار SPSS نسخه 21 انجام گرفت.
نتایج: میانگین هموسیستئین در گروههای با گرفتگی یک رگ، دو رگ و سه رگ به طور معنی داری بالاتر از دو گروه نرمال و سالم بود (P<0.001). نتایج آنالیز رگرسیون لجستیک نشان دادند افزایش یک واحد هموسیستئین سبب افزایش شانس درگیری عروقی در افراد با درگیری یک رگ، دو رگ و سه رگ به ترتیب 1.461 (1. 326-1. 611), 1.289 (1.125-1.414), 1.235 (1.053-1.273) می شود. که به طور معنی داری بالاتر از گروههای نرمال و سالم بود  (P <0.001).
نتیجه گیری:  نتایج مطالعه حاضر نشان دادند که افزایش یک واحد غلظت هموسیستئین به عنوان یک ریسک فاکتور مستقل می تواند سبب شیوع بیشتر و همچنین پیشرفت تنگی عروق شود.

کلیدواژه‌ها

عنوان مقاله [English]

Evaluation of serum homocysteine levels with coronary artery disease in angiographic patients

نویسندگان [English]

  • Susan Darroudi 1
  • Sara Saffar 1
  • Emadzadeh Maryam 2
  • Behzad Senobari 3
  • Majid Ghayour-mobarhan 4
  • Mohsen Mouhebati 5
1 Postdoctoral Student, UNESCO International Center for Basic Sciences Related to Human Health and Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Assistant Professor of Community Medicine, Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3 Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Professor, Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Postdoctoral Student, UNESCO International Center for Basic Sciences Related to Human Health and Nutrition, Mashhad
5 Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Introduction: Cardiovascular disease is estimated the cause of 17.3 million deaths annually in the world and 27.4% of deaths in Iran. Since the common risk factors cannot currently predict all causes of cardiovascular disease, researchers have suggested that other factors such as oxidative stress, trace elements, inflammation, and homocysteine may be potential contributors to cardiovascular disease. Therefore, in this study, we assess the association of serum level of homocysteine with the severity of coronary artery involvement.
Material and Methods: In this cross-sectional study, 347 patients referred to Ghaem Hospital for angiography and 103 healthy individuals without cardiac symptoms were evaluated. Subjects were divided into five groups with more than 50% stenosis of one (1), two (2), and three (3) arteries, individuals with normal angiography or less than 50% involvement (4), and healthy subjects (5). Serum homocysteine level was measured by ELISA at Bou-ali Research Institute. Statistical data analysis was performed using SPSS software version 21.
Results: In this research, 106 healthy people, 91 normal people, and 80, 87, and 89 people with stenosis in one, two, and three arteries, respectively were studied. The mean homocysteine in the groups with stenosis of one, two, and three vessels was significantly higher than the normal and healthy groups (P <0.001). The results of logistic regression analysis showed that increment of one unit of homocysteine raised the chance of vascular involvement in people with one, two, and three-vessel involvement into 1.235 (1. 053-1. 273), 1.289 (1.125-1.414), 1.461 (1.326-1.611), respectively (P <0.001)
Conclusion: The results of the present study showed that increase in concentration of homocysteine as an independent risk factor can lead to greater prevalence and progression of vascular stenosis.

کلیدواژه‌ها [English]

  • Coronary angiography
  • homocysteine
  • Aortic stenosis

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مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 64، شماره 2
خرداد و تیر 1400
صفحه 2763-2774

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