تأثیر هشت هفته تمرین ترکیبی بر مقادیر P3NP، CAF و IGF-1 روی بیماران CABG

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه تربیت بدنی، دانشگاه آزاد اسلامی واحد نیشابور، نیشابور، ایران

2 دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران. نویسنده مسئول

3 گروه تربیت بدنی، دانشگاه ازاد اسلامی واحد نیشابور، نیشابور، ایران.

4 گروه تربیت بدنی، دانشگاه ازاد اسلامی واحد نیشابور، نیشابور، ایران

چکیده

مقدمه: پژوهش حاضر باهدف بررسی تأثیر هشت هفته تمرین ترکیبی بر مقادیر P3NP، CAF و IGF-1 روی بیماران CABG انجام شد.
روش کار: تعداد 24 نفر جامعه­ی مرد میان‌سال CABG در این مطالعه شرکت کردند. سپس شرکت‌کنندگان بصورت تصادفی به دو گروه 12 نفره تمرین ترکیبی (میانگین سنی 47/6±  58/54 سال) و گروه کنترل (میانگین سنی 50/7± 16/56 سال) تقسیم شدند. شاخص‌های آنتروپومتریک و متغیرهای خونی P3NP، CAF و IGF-1 سرمی قبل و بعد دوره تمرینی تهیه و مورد تجزیه‌وتحلیل قرار گرفت. برنامه تمرین ترکیبی برای مدت هشت هفته با تواتر سه جلسه و زیر نظر متخصصین بازتوانی قلبی انجام شد. از آزمون آماری اندازه‌های تکراری برای تجزیه‌وتحلیل داده‌ها استفاده شد.
نتایج: تمرین ترکیبی با کاهش معنی‌دار سطوح سرمی P3NP همراه بود (001/0=p)؛ اما این تغییرات مشاهده‌شده نسبت به گروه کنترل معنی‌دار نبود (334/0=p). همچنین افزایش معنی‌دار در سطوح سرمی CAF در پس‌آزمون نسبت به پیش‌آزمون مشاهده گردید (280/0=p) و تغییرات بین گروه کنترل و گروه‌ تمرین معنی‌دار بود(038/0= p). از سویی دیگر افزایش معنی‌دار سطوح سرمی IGF-1 در پس‌آزمون نسبت به پیش‌آزمون مشاهده شد همراه بود(001/0=p)، اما سطوح سرمی IGF-1 نسبت به گروه کنترل معنی‌دار نبود (280/0=p).
نتیجه ­گیری: یک دوره تمرین ترکیبی کوتاه‌مدت در بیماران CABG سبب بالا رفتن IGF-1 و CAF گردید؛ درحالی‌که تغییری در سطوح P3NF مشاهده نگردید. تحقیقات بیشتری لازم است تا اثر تمرین ترکیبی بر بیماران CAGB بر این شاخص‌ها انجام شود.

کلیدواژه‌ها

عنوان مقاله [English]

The Investigate of Effect Eight Weeks of Combined Exercise on P3NP, CAF and IGF-1 on CABG Patients

نویسندگان [English]

  • Sahar Alaei 1
  • Amir Rashidlamir 2
  • Rambod Khajei 3
  • Ameneh Barjaste yazdi 4
1 Department of Physical Education, Neyshabour Branch, Islamic Azad University, Neyshabour, Iran
2 Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
3 Department of Physical Education, Neyshabour Branch, Islamic Azad University, Neyshabour, Iran
4 Department of Physical Education, Neyshabour Branch, Islamic Azad University, Neyshabour, Iran
چکیده [English]

Introduction
This study aimed to investigate the effect of eight weeks of combined exercise on P3NP, CAF and some sarcomopia factors in CABG patients.
Materials and Methods
24 CABG middle-aged men participated in this study. Then the participants were randomly divided into two groups of 12-person combination exercise (mean age 54.58 ±6.47 years) and control group (mean age 50.70 ±7.70 years). Anthropometric indices and serum P3NP, CAF and IGF-1 blood parameters were prepared and analyzed before and after training. The eight-week combined exercise program was conducted in three sessions with the supervision of cardiac rehabilitation specialists. Repeated measures statistical test was used for data analysis.
Results
Combined exercise was associated with a significant decrease in serum P3NP levels (p=0.001), but these changes were not significant compared to the control group (p=0.334). But these changes were not significant compared to the control group (p=0.334). There was also a significant increase in serum CAF levels in the post-test compared to the pre-test (p=0.02) and the differences between the control group and the training group were significant (p=0.038). On the other hand, a significant increase in serum IGF-1 levels was observed in the post-test compared to the pre-test (p=0.001), but the serum levels of IGF-1 were not significant in the control group (p=0.280).
Conclusion
A short-term combination training in CABG patients increased IGF-1 and CAF, but no change in P3NF levels. Further research is needed to investigate the effect of combined exercise on CAGB patients on these indices.

کلیدواژه‌ها [English]

  • Coronary artery bypass grafting
  • Amino terminal levels of type III procollagen
  • C-Agrin terminus fragment
  • Combined exercise

مراجع

  1. Roger VL,Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics-
    -2012 update: a report from the American Heart Association. Circulation. 2012;125(1):e2-e220.
    2. Sakuma K, Yamaguchi A. Sarcopenia and age-related endocrine function. International journal of endocrinology.
    2012;2012.
    3. Narici MV, Reeves ND, Morse CI, Maganaris CN. Muscular adaptations to resistance exercise in the elderly. Journal
    of musculoskeletal and neuronal interactions. 2004;4(2):161-4.
    4. Malafarina V, Úriz-Otano F, Iniesta R, Gil-Guerrero L. Sarcopenia in the elderly: diagnosis, physiopathology and
    treatment. Maturitas. 2012;71(2):109-14.
    5. Lambert CP, Evans WJ. Effects of aging and resistance exercise on determinants of muscle strength. Journal of the
    American Aging Association. 2002;25(2):73-8.
    6. Seo D-I, Jun T-W, Park K-S, Chang H, So W-Y, Song W. 12 weeks of combined exercise is better than aerobic
    exercise for increasing growth hormone in middle-aged women. International Journal of Sport Nutrition and
    Exercise Metabolism. 2010;20(1):21-6.
    7. Cadore EL, Izquierdo M, Pinto SS, Alberton CL, Pinto RS, Baroni BM, et al. Neuromuscular adaptations to
    concurrent training in the elderly: effects of intrasession exercise sequence. Age. 2.891-903:)3(35;013
    8. Bijeh N, Hejazi K. The effect of a six-month aerobic exercise on levels of GH, IGF-1 and GH/IGF-1 ratio serum in
    sedentary middle-aged women. SSU_Journals. 2013;21(4):415-27.
    9. Fish DE, Krabak BJ, Johnson-Greene D, DeLateur BJ. Optimal resistance training: comparison of DeLorme with
    Oxford techniques. American journal of physical medicine & rehabilitation. 2003;82(12):903-9.
    10. Feng Z, Levine AJ. The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends
    in cell biology. 2010;20(7):427-34.
    11. Latres E, Amini AR, Amini AA, Griffiths J, Martin FJ, Wei Y, et al. Insulin-like growth factor-1 (IGF-1) inversely
    regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin
    (PI3K/Akt/mTOR) pathway. Journal of Biological Chemistry. 2005;280(4):2737-44.
    12. Perrini S, Laviola L, Carreira MC, Cignarelli A, Natalicchio A, Giorgino F. The GH/IGF1 axis and signaling
    pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis.
    Journal of Endocrinology. 2010;205(3):201-10.
    13. Chen HT, Chung YC, Chen YJ, Ho SY, Wu HJ. Effects of Different Types of Exercise on Body Composition,
    Muscle Strength, and IGF‐1 in the Elderly with Sarcopenic Obesity. Journal of the American Geriatrics Society.
    2017;65(4):827-32.
    14. Saket A, Izaddoust F, Shabani R. The effect of combine training and green coffee consumption on the serum level
    of testosterone, IGF-1 and cortisol hormone in overweight and obese women. J Neyshabur Univ Med Sci.
    2017;5(2):65-76.
    15. A FMbLbER. The Effect of Different Order of Strength and Endurance Combined Exercise on Resting Levels of
    IL-15 and IGF-1 in Elderly Women. Journal of Applied Exercise Physiology. 2017;12(24.12:)
    16. Bagheri L, Faramarzi M, Banitalebi E, Azamian Jazi A. The effect of sequence order of combined training (strength
    and endurance) on Myostatin, Follistatin and Follistatin/Myostatin ratio in older women. Sport Physiology.
    2015;7(26):143-64.
    17. Fragala MS, Jajtner AR, Beyer KS, Townsend JR, Emerson NS, Scanlon TC, et al. Biomarkers of muscle quality:
    N‐terminal propeptide of type III procollagen and C‐terminal agrin fragment responses to resistance exercise training
    in older adults. Journal of cachexia, sarcopenia and muscle. 2014;5(2):139-48.
    18. Fragala MS, Kenny AM, Kuchel GA. Muscle quality in aging: a multi-dimensional approach to muscle functioning
    with applications for treatment. Sports Medicine. 2015;45(5):641-58.
  2. 19. Barasch E, Gottdiener JS, Aurigemma G, Kitzman DW, Han J, Kop WJ, et al. The relationship between serum
    markers of collagen turnover and cardiovascular outcome in the elderly: the Cardiovascular Health Study.
    Circulation: Heart Failure. 2011;4(6):733-9.
    20. Cicoira M, Rossi A ,Bonapace S, Zanolla L, Golia G, Franceschini L, et al. Independent and additional prognostic
    value of aminoterminal propeptide of type III procollagen circulating levels in patients with chronic heart failure.
    Journal of cardiac failure. 2004;10(5):403-1.1
    21. Ruiz-Ruiz FJ, Ruiz-Laiglesia FJ, Samperiz-Legarre P, Lasierra-Diaz P, Flamarique-Pascual Á, Morales-Rull JL, et
    al. Propeptide of procollagen type I (PIP) and outcomes in decompensated heart failure. European journal of internal
    medicine. 2007;18(2.129-34:)
    22. Haghighi AmRaMHA. The Effect of Resistance Training with and without Blood Flow Restriction on Serum
    Concentration of CAF, P3NP and Muscular Function in Elderly Women. Journal of sport biosciences.
    2018;10(3):17.
    23. Bolliger MF, Zurlinden A ,Lüscher D, Bütikofer L, Shakhova O, Francolini M, et al. Specific proteolytic cleavage
    of agrin regulates maturation of the neuromuscular junction. J Cell Sci. 2010;123(22):3944-55.
    24. Deschenes MR, Roby MA, Eason MK, Harris MB. Remodeling of the neuromuscular junction precedes sarcopenia
    related alterations in myofibers. Experimental gerontology. 2010;45(5):389-93.
    25. Bondoc I, Cochrane SK, Church TS, Dahinden P, Hettwer S, Hsu F-C, et al. Effects of a one-year physical activity
    program on serum C-terminal Agrin Fragment (CAF) concentrations among mobility-limited older adults. The
    journal of nutrition, health & aging. 2015;19(9):922-7.
    26. Drey M, Sieber C, Bauer J, Uter W, Dahinden P, Fariello R, et al. C-terminal Agrin Fragment as a potential marker
    for sarcopenia caused by degeneration of the neuromuscular junction. Experimental gerontology. 2013;48(1):76-80.
    27. M FANMSMP. Comparison of Two Rehabilitate Continuous and Interval Incremental Individualized Exercise
    Training Methods on Some Structural and Functional Factors of Left Ventricle in Heart Patients after Coronary
    Artery Bypass Graft Surgery (CABG). The Scientific Journal of Rehabilitation Medicine (SJRM). 2018;8(4):21.
    28. Adams BJ, Carr JG, Ozonoff A, Lauer MS, Balady GJ. Effect of exercise training in supervised cardiac rehabilitation
    programs on prognostic variables from the exercise tolerance test. The American journal of cardiology.
    2008;101(10):1403-7.
    29. Choo J, Burke LE, Hong KP. Improved quality of life with cardiac rehabilitation for post-myocardial infarction
    patients in Korea. European journal of cardiovascular nursing. 2007;6(3):166-71.
    30. Siavoshi S, Roshandel M, Zareyan A, Ettefagh L. The effect of cardiac rehabilitation care plan on quality of life in
    patients undergoing coronary artery bypass surgery. Alborz university medical journal. 2013;2(4):217-26.
    31. Pollock ML, Franklin BA, Balady GJ, Chaitman BL, Fleg JL, Fletcher B, et al. Resistance exercise in individuals
    with and without cardiovascular disease: benefits, rationale, safety, and prescription an advisory from the committee
    on exercise, rehabilitation, and prevention, council on clinical cardiology, American Heart Association. Circulation.
    2000;101(7):828-33.
    32. Bode M. Characterization of type I and type II collagens in human tissues. 2002.
    33. Berry SD, Ramachandran VS, Cawthon PM, Gona P, McLean RR, Cupples LA, et al. Procollagen type III Nterminal peptide (P3NP) and lean mass: a cross-sectional study. The Journal of frailty & aging/[editor in chief M
    Cesari]. 2013;2(3):129.
    34. Bhasin S, He EJ, Kawakubo M, Schroeder ET, Yarasheski K, Opiteck GJ, et al. N-terminal propeptide of type III
    procollagen as a biomarker of anabolic response to recombinant human GH and testosterone. The Journal of Clinical
    Endocrinology & Metabolism. 2009;94(11):4224-33.
    35. Socratis K, Kostas D, Athanasios D, Eleni D, Dimitrios K. The Influence of Physical Training on Blood Levels of
    Human Growth Hormone, Testosterone and Procollagen in Young Rowers. International Journal of Kinesiology
    and Sports Science. 2016;4(3):63-9.
    36. Mendis S, Puska P, Norrving B, Organization WH. Global atlas on cardiovascular disease prevention and control:
    Geneva: World Health Organization; 2011.
    37. Horiguchi M, Ota M, Rifkin DB. Matrix control of transforming growth factor-β function. The Journal of
    Biochemistry. 2012;152(4):321-9.
  3. 38. Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Umansky KB, Yifa O, et al. The extracellular matrix protein
    agrin promotes heart regeneration in mice. Nature. 2017;54.179:)7662(7
    39. Apel PJ, Ma J, Callahan M, Northam CN, Alton TB, Sonntag WE, et al. Effect of locally delivered IGF‐1 on nerve
    regeneration during aging: an experimental study in rats. Muscle & Nerve: Official Journal of the American
    Association of Electrodiagnostic Medicine. 2010;41(3):335-41.
    40. Sattler FR. Growth hormone in the aging male. Best practice & research Clinical endocrinology & metabolism.
    2013;27(4):541-55.
    41. Gibney J, Healy M-L, Sönksen PH. The growth hormone/insulin-like growth factor-I axis in exercise and sport.
    Endocrine reviews. 2007;28(6):603-24.
    42. Karabulut M, Abe T, Sato Y, Bemben MG. The effects of low-intensity resistance training with vascular restriction
    on leg muscle strength in older men. European journal of applied physiology. 2010;108(1):147.
    43. Jones TW, Walshe IH, Hamilton DL, Howatson G, Russell M, Price OJ, et al. Signaling responses after varying
    sequencing of strength and endurance training in a fed state. International journal of sports physiology and
    performance. 2016;11(7):868-75.
    44. Eklund D, Schumann M, Kraemer WJ, Izquierdo M, Taipale RS, Häkkinen K.
    45. Acute endocrine and force responses and long-term adaptations to same-session combined strength and endurance
    training in women. The Journal of Strength & Conditioning Research. 2016;30(1):164-75.
    46. McGawley K, Andersson P-I. The order of concurrent training does not affect soccer-related performance
    adaptations. International journal of sports medicine. 2013;34(11):983-90.
    47. Schumann M, Küüsmaa M, Newton RU, Sirparanta A-I, Syväoja H, Häkkinen A, et al. Fitness and lean mass
    increases during combined training independent of loading order. Medicine and science in sports and exercise.
    2014;46(9(
    48. Jorge MLMP, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz ALD, et al. The effects of aerobic,
    resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin
    signaling in patients with type 2 diabetes mellitus. Metabolism. 2011;60(9):1244-52.
مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 64، شماره 3
مرداد و شهریور 1400
صفحه 3103-3116

فایل ها

هم رسانی

ارجاع به این مقاله

آمار